Jim and Tipsters,
My understanding of valium is that it enhances the ability of the GABA receptor
to open chloride channels in the GABA receptor complex. Thus, an abundance of
GABA receptors coupled with valium would facilitate behavioral disinhibition. I
might point out that neural inhibition may not necessarily lead to behavioral
inhibition. An example is the ability of Valium to facilitate aggressive
behavior. See the following for a review of the benzodiazepine/aggression
connection:
Taylor, S.P. & Chermack, S.T. (1993). Alcohol, drugs, and human aggression.
Journal of Studies on Alcohol (Suppl. 11), 78-88.
Taylor, S.P. & Hulsizer, M.R. (1998). Psychoactive drugs and aggression. In R.G.
Geen and E.I. Donnerstein (Eds.), Human aggression: Theories, research, and
implications for social policy (pp. 131-165). San Diego: Academic Press.
Enjoy!
Mike Hulsizer
Jim Clark wrote:
Perhaps I'm showing my ignorance about some fine point, but as
someone who has thought quite a bit about inhibition and
behavior, I would have thought the problem (i.e., lack of
inhibition) was not an excess of GABA receptors, but rather a
GABA deficit that could be overcome by valium or like drugs (or
an effective Cognitive-Behavioural program, of course). Perhaps
Michael S. would like to leave his brain to science, like
Einstein?
> On Tue, 22 Jun 1999, Michael Hulsizer wrote:
> > Hmmmm...it sounds like a nice go-no-go test of disinhibition.
> > Clearly, Michael seems to error on the go side...maybe he
> > suffers from an abundance of GABA-receptors (gamma-aminobutyric
> > acid). I would hate to see what type of post would result
> > after the consumption of a nice 10 mg dose of valium! The
> > enhancement of an already abundant number of GABA receptors
> > would result in a particular interesting set of posts! :-)
>
--
Michael Hulsizer
Webster University
mailto:[EMAIL PROTECTED]
