On 31 Dec 2010 at 12:26, DeVolder Carol L wrote:

> My son told me about this site. Maybe I'm the last person to discover it, but 
> I thought I'd share it just in
> case. It seems to be a useful resource. So far I've only looked at the 
> anatomy of a neuron and
> sodium-potassium pumps. I'd be interested in others' opinions. 
> 
> http://www.khanacademy.org/

I'm mightily impressed. It's an staggering body of work for one 
person to create, and he seems to be a gifted teacher. PBS, among 
others, has taken note of his contribution, and if PBS (The USA 
television equivalent of the BBC) cares, it must be important (Allen 
Esterson would disagree about PBS, but that's another story).  
(See http://tinyurl.com/27qo5mr for the PBS report on Khan).

It also seems to me to be revolutionary, opening up high school and 
university-level tutoring to millions who are without easy access to 
such education.  As the truly cheap laptop becomes a reality and is 
made available around the world, all any bright third-world person 
would need is one of those, and the url to Khan's academy. How many 
more potential Ramanujans are out there who could be kick-started 
with something like this?

I checked out the "anatomy of a neuron" lesson, expecting the 
standard misconception about this topic. I thought my fear about to 
comfirmed when he used as his drawn example a motoneuron.  I was 
instead pleasantly surprised.

He did not define a dendrite according to the incorrect but widely-
used definition as the part of the neuron which conducts a signal 
_towards_ the soma. Instead, he defined it correctly as the part of 
the neuron which _receives_ a signal, a definition first advcated by 
Bodian in a classic paper in _Science_.  The problem with the 
standard incorrect definition is that it only works out for one type 
of neuron--the motoneuron--and leads to contradictions when applied 
to others, notably the myelinated bipolar neuron. Focusing on 
direction of travel in relation to the soma is also of no 
physiological significance, while a definition in terms of receiving 
and sending information is.

He might have said a bit more about these definitions, perhaps noted 
that the myelin is provided by oligodendrocytes, not Schwann cells, 
in the CNS, and given some examples of other types of neuron. But 
within the limits of the short lesson on YouTube which he set 
himself, it's a pretty good presentation. Bravo, Sal Khan! And thank 
you, Carol, for pointing it out.

As for Miguel's post asking about the Lin theory of the sodium pump. 
I haven't heard anything about this, and a Google search seems to 
turn up mostly Lin himself promoting his work. One exception I found 
is a 1985 (or so) book review in _New Scientist_ by a chemist, who 
calls Lin's work "soft science", but says it's still good to have 
such dissenters. 

The topic is too difficult for me to evaluate. However, given the 
great acceptance of the sodium-potassium pump idea, its evident 
success in understanding and predicting neuronal function,  and the 
total absence of Lin's claims in textbooks, I'd be very cautious 
about Lin. It sounds to me as though it could be another case of an 
off-the-wall dissenter, such as Peter Duesberg, who claims that HIV 
doesn't cause AIDS.

Stephen
--------------------------------------------
Stephen L. Black, Ph.D.          
Professor of Psychology, Emeritus   
Bishop's University
Sherbrooke, Quebec, Canada               
e-mail:  sblack at 
ubishops.ca
---------------------------------------------

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