On 11/7/2011 5:55 PM, William Scott wrote:



It is interesting that Animal IRB's often set a standard which makes it
difficult to simply perform replication studies with animals. This is
sometimes true for human IRB's as well. Replication attempts must be
shown to be strongly justified in order to gain approval, the argument
being that "we already know that" and shouldn't subject animals to any
hardship that "doesn't further our knowledge".

Bill Scott


Bill raises an important point about animal research. I am a member of the ASU Institutional Animal Care and Use Committee (IACUC). The ASU application form for animal use requires the PI to report the results of database searches to make sure that the work doesn't unnecessarily duplicate previous work. Here are the instructions from the ASU form:

"Provide below a brief narrative description of the methods and sources that were used to determine that the Proposed activities do not unnecessarily duplicate previous experiments. (Sources might include Biological Abstracts, Index Medicus (PubMed or Ovid databases), Agricola, ISI Web of Science, and Chemical Abstracts)."

"Unnecessarily" does give a researcher a lot of wiggle room but the overall tone of the form discourages replications.

Ken

------------------------------------------------------------------------
Kenneth M. Steele, Ph. D.                        [email protected]
Professor and Assistant Chairperson
Department of Psychology                 http://www.psych.appstate.edu
Appalachian State University
Boone, NC 28608
USA
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