I'm also experiencing this problem in Ubuntu 11.10.  I should also note
I've been running into file system problems w/ bad inodes and the FS
being mounted read-only.

root@enterprise:~$ aptitude clean
[ ERR] Reading package lists
E: Unable to synchronize mmap - msync (5: Input/output error)
E: The package lists or status file could not be parsed or opened.

** Changed in: apt (Ubuntu)
       Status: Expired => Incomplete

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https://bugs.launchpad.net/bugs/796849

Title:
  E: Unable to synchronize mmap - msync (5: Input/output error) E: The
  package lists or status file could not be parsed or opened. E:
  _cache->open() failed, please report.

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