Hi, I think I'm having the same issue:
Linux ricardo-N24-25BU 4.8.0-28-generic #30-Ubuntu SMP Fri Nov 11 14:03:52 UTC 2016 x86_64 x86_64 x86_64 GNU/Linux lsb_release -a No LSB modules are available. Distributor ID: Ubuntu Description: Ubuntu 16.10 Release: 16.10 Codename: yakkety Just upgraded to 16.10 last night, after bootup, I connect to a work VPN (OpenVPN + Pritunl) which was working ok so far. route -n shows the new routes, and resolve.conf is correctly updated with the VPN DNS nameserver Any direct query: dig, nslookup, ip route get {host} resolves correctly using the VPN DNS But any other command: ping, telnet, mysql, etc resolves without the VPN DNS (unless instructed otherwise explicitely) Quick solution was: sudo systemctl restart systemd-resolved.service -- You received this bug notification because you are a member of Ubuntu Bugs, which is subscribed to Ubuntu. https://bugs.launchpad.net/bugs/1624317 Title: systemd-resolved breaks VPN with split-horizon DNS To manage notifications about this bug go to: https://bugs.launchpad.net/systemd/+bug/1624317/+subscriptions -- ubuntu-bugs mailing list ubuntu-bugs@lists.ubuntu.com https://lists.ubuntu.com/mailman/listinfo/ubuntu-bugs