Lenovo IdeaPad 720s (i5-8250U), the same issue.

On resume, I get:
[  213.347656] usb 1-7: device descriptor read/64, error -110

➜  ~ lsusb -t
/:  Bus 02.Port 1: Dev 1, Class=root_hub, Driver=xhci_hcd/6p, 5000M
    |__ Port 2: Dev 2, If 0, Class=Mass Storage, Driver=usb-storage, 5000M
/:  Bus 01.Port 1: Dev 1, Class=root_hub, Driver=xhci_hcd/12p, 480M
    |__ Port 5: Dev 2, If 1, Class=Video, Driver=uvcvideo, 480M
    |__ Port 5: Dev 2, If 0, Class=Video, Driver=uvcvideo, 480M
    |__ Port 6: Dev 3, If 0, Class=Vendor Specific Class, Driver=, 12M
    |__ Port 7: Dev 5, If 0, Class=Wireless, Driver=btusb, 12M
    |__ Port 7: Dev 5, If 1, Class=Wireless, Driver=btusb, 12M

This way, i was getting my BT adapter disconnected.
But also I was experiencing a USB3 flash drive reconnecting unexpectedly during 
normal operation (no sleep/resume).

'pci=nomsi iommu=soft' helped, at least for now.

➜  ~ lsb_release -a                  
No LSB modules are available.
Distributor ID: Ubuntu
Description:    Ubuntu 18.04 LTS
Release:        18.04
Codename:       bionic
➜  ~ uname -a      
Linux vshymanskyy-720S 4.15.0-20-generic #21-Ubuntu SMP Tue Apr 24 06:16:15 UTC 
2018 x86_64 x86_64 x86_64 GNU/Linux

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https://bugs.launchpad.net/bugs/1413440

Title:
  USB stops working after a while (xhci_hcd 0000:00:14.0: Timeout while
  waiting for setup device command)

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