@s-breedveld thanks. I'm absolutely sure as:

➜  ~ cat /proc/cmdline
BOOT_IMAGE=/boot/vmlinuz-4.15.0-22-generic 
root=UUID=69ba76e3-5381-4011-99c1-195ad0e6d288 ro quiet splash pci=nomsi 
iommu=soft vt.handoff=1

I'll try intel_iommu=off. As I said, Intel i5-8250U.

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https://bugs.launchpad.net/bugs/1413440

Title:
  USB stops working after a while (xhci_hcd 0000:00:14.0: Timeout while
  waiting for setup device command)

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