It looks to me like you are likely trying to shove too much mail into
amavisd-new given the available RAM/CPU/disk I/O on the box in question.

smtp inet n - n - 20 smtpd
  -o smtpd_proxy_filter=127.0.0.1:10024

means that you can be making up to 20 connections to amavisd-new at
once.  You should start by defining a service for the content filter in
your master.cf with a lower connection limit.  This is described in
http://www.postfix.org/FILTER_README.html#advanced_filter

I'd start by cutting it in half (10) and then adjust up or down as
needed.

-- 
amavis-new floods harddisk
https://bugs.launchpad.net/bugs/240521
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