Drug Reduces Cardiac Arrest by 21 Percent

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TUESDAY, Sept. 7 (HealthDayNews) -- The drug ramipril cuts the rate
of sudden cardiac death and nonfatal cardiac arrest by 21 percent in
people at high risk of heart attack or stroke.

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That's the conclusion of a Canadian study in the Sept. 7 issue of
Circulation.


Ramipril is an angiotensin-converting enzyme (ACE) inhibitor, a class
of drugs often used to treat heart failure or left ventricular
systolic dysfunction. But none of the patients in this study had
either condition, the study authors noted.


The researchers analyzed data on 9,297 men and women, average age 66,
at high risk for heart attack or stroke who enrolled in the Heart
Outcomes Prevention Evaluation (HOPE) study. They were randomly
assigned to take either ramipril, vitamin E or a placebo.


After an average of 4.5 years of treatment, 3.3 percent of the people
taking ramipril had suffered either sudden cardiac death or nonfatal
cardiac arrest, compared to 4.2 percent of those taking the placebo.
There was no significant difference in the outcomes between those
taking vitamin E and those taking the placebo.


Previous studies also found similar protective effects for other ACE
inhibitors.


"The new findings should remind physicians of the importance of ACE
inhibitor therapy. We now know that these drugs are not only good in
preventing overall cardiovascular death, but also in preventing
specific causes of death," study lead author Koon K.Teo, a professor
of medicine at McMaster University in Hamilton, said in a prepared
statement.


The study received funding from Aventis Pharma Inc.

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