Hi Biomart, I have a human snp list generated by the software "aaChanges" and was wondering if there is a way of using this list to generate a "personalised" human proteome? Here is an example of the file:
chr1 888658 888659 C ENST00000327044 Ile:Val 300 T chr1 906258 906259 G/T ENST00000379407 Gly:Gly/Val 162 G chr1 906258 906259 G/T ENST00000379410 Gly:Gly/Val 162 G chr1 906258 906259 G/T ENST00000379409 Gly:Gly/Val 202 G chr1 949607 949608 A/G ENST00000379389 Ser:Asn/Ser 83 G chr1 979381 979382 C/T ENST00000379370 Arg:Arg/Trp 660 C chr1 979381 979382 C/T ENST00000539069 Arg:Arg/Trp 82 C chr1 1019858 1019859 A/G ENST00000437760 Val:Val/Ala 178 A chr1 1154307 1154308 T ENST00000465727 Ser:Asn 198 C chr1 1167766 1167767 A/G ENST00000379198 Gly:Arg/Gly 37 G chr1 1245175 1245176 C/T ENST00000379031 Arg:Arg/Trp 197 C chr1 1249186 1249187 A/G ENST00000528879 Arg:Cys/Arg 273 G chr1 1334474 1334475 C/G ENST00000400809 Thr:Ser/Thr 71 G chr1 1334474 1334475 C/G ENST00000496007 Thr:Ser/Thr 71 G chr1 1334474 1334475 C/G ENST00000481223 Thr:Ser/Thr 71 G chr1 1334474 1334475 C/G ENST00000488340 Thr:Ser/Thr 71 G chr1 1334474 1334475 C/G ENST00000408918 Thr:Ser/Thr 71 G chr1 1334474 1334475 C/G ENST00000425598 Thr:Ser/Thr 71 G chr1 1418444 1418445 C ENST00000378741 Trp:Arg 105 T chr1 1418444 1418445 C ENST00000378736 Trp:Arg 104 T chr1 1424581 1424582 C ENST00000378737 Gln:Pro 224 A chr1 1424582 1424583 T ENST00000378737 Gln:His 224 G chr1 1425635 1425636 A ENST00000378737 Arg:Lys 249 G chr1 1431164 1431165 C/T ENST00000378737 Pro:Pro/Ser 473 C chr1 1431164 1431165 C/T ENST00000308647 Pro:Pro/Ser 639 C chr1 1455651 1455652 G/T ENST00000378756 Ala:Ala/Ser 216 G chr1 1455651 1455652 G/T ENST00000378755 Ala:Ala/Ser 264 G Any thoughts on how I might do this or any alternative approaches I might use? Best Wishes, David. __________________________________ Dr David A. Matthews Senior Lecturer in Virology Room E49 Department of Cellular and Molecular Medicine, School of Medical Sciences University Walk, University of Bristol Bristol. BS8 1TD U.K. Tel. +44 117 3312058 Fax. +44 117 3312091 [email protected]
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