GitHub user ingox added a comment to the discussion: Architectural Blueprint 
for True Multi-Region - Single Management Plane

It is mostly a question of the latency between the datacenters.

**High latency:**

- You'll need to go with option 4.

**Medium latency:**

- You'll go with option 3. Make sure active management server and writable 
database are in the same location. For DR purposes you'll have an offline 
management server and a async replication of your database. Latency between 
your hosts and the management are not that critical than between management and 
database.

**Low latency:**
- You can place management servers and databases across your locations.

GitHub link: 
https://github.com/apache/cloudstack/discussions/13508#discussioncomment-17472430

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