GitHub user bhouse-nexthop closed the discussion with a comment: Alternative to 
MySQL

if you need a cross-region cluster, yeah, things get way more complicated 
unless your regions are fairly close. 

I've run datacenters before within 20 or so ms of eachother (stable dedicated 
links like wavelengths, not public internet) with a stretched galera with 
success, mostly because of the opportunistic certification ... but I didn't 
explicitly try that with cloudstack.

GitHub link: 
https://github.com/apache/cloudstack/discussions/12513#discussioncomment-18481032

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