Hi,

> Out of curiosity, as Flex matures under Apache's watch what is the way 
> forward for data-centric web applications?
There was a corporation with Adobe and Zend that created the "Flashbuilder for 
PHP", an approach to provide additionally IDE functionality including code 
generation to simplify Flex/PHP development.... but it's discontinued I think.
http://www.adobe.com/devnet/flash-builder/articles/flashbuilder-php-part1.html

Moreover there're some "outdated" open source projects with the goal to speed 
up the PHP/Flex development process, e.g.:
http://fredericbournival.com/sphex/
(Google with words like "PHP, Flex, ORM, Doctrine" to find other approaches)

>I'm unsure if I need (or should consider) a framework like Zend or WebOrb to 
>assist. It may be determined by my client's corporate server restrictions.
If you'd like to connect your backend via AMF you should I think.
But these libraries are just PHP classes. Using Zend, there's no need to deal 
with the complete Zend framework, just consider the Zend_AMF module.
If you've questions regarding PHP/MySQL feel free to contact  me.

As an alternative to the venerable PHP/MySQL perhaps you 'd like to take a 
gander to hip technologies like node.js and noSQL databases (If your data model 
allows it)  ;-)
http://www.rivellomultimediaconsulting.com/node-js-for-flash-and-flex-introduction/
http://docs.mongodb.org/ecosystem/drivers/node-js/

Connect your AS3 application directly to  MongoDB  (Don't know if this project 
is still active):
https://code.google.com/p/jmcnet-full-mongo-flex-driver/


Olaf






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