Hi Richard,
Perl 5.6.1 simply didn't work properly. It caused Amavis & SA to strip emails of their subject lines, failed to scan properly, had real problems with spawning multiple processes, and reported errors in spamassassin --lint --debug, many of which I was eventually able to resolve; but the worst problems remained, including an inability to run DCC.
hm... that's interesting. I just checked the top-level INSTALL file and it says that Perl 5.6.1 is just fine. When I manually invoke spamc, it scans just fine. amavisd-new leaves out some tests. Lint does not tell me about any errors.
Florian