Yes, it is hard to believe but it is wonderful. [I just wonder if we aren't creating a generation of sugar babies!!!] I have put in PICCs in neonates using this product, as well as IVs in neonates and infants. One of the products we were using was called Sweet-Ease, but we are now using a generic brand. [of course]. Here are a couple of articles on this topic and a link to one of them. I have also read one in a phlebotomy publication on this working as well. There are more articles on Medline. anne marie
Gradin M, Eriksson M, Holmqvist G, Holstein A, Schollin J. Pain reduction at venipuncture in newborns: oral glucose compared with local anesthetic cream. Pediatrics. 2002 Dec;110(6):1053-7. OBJECTIVE: A number of studies have shown that orally administered sweet-tasting solutions reduce signs of pain during painful procedures. The local anesthetic cream EMLA has recently been shown to be safe for use in neonates. This study compared the pain-reducing effect of orally administered glucose with that of EMLA cream during venipuncture in newborns. METHODS: Randomized, controlled, double-blind study including 201 newborns undergoing venipuncture for clinical purposes. Ninety-nine of the newborns received EMLA on the skin and orally administered placebo (sterile water), and 102 received glucose 30% orally and placebo (Unguentum Merck) on the skin. Symptoms associated with pain at venipuncture were measured with the Premature Infant Pain Profile (PIPP) scale (also validated for full-term infants). Heart rate and crying time were recorded. RESULTS: There were no differences in background variables between the 2 groups. The results shows that the PIPP scores were significantly lower in the glucose group (mean: 4.6) compared with the EMLA group (mean: 5.7). The duration of crying in the first 3 minutes was significantly lower in the glucose group (median: 1 second) than in the EMLA group (median: 18 seconds). There were significantly fewer patients in the glucose group who were scored having pain (defined as PIPP score above 6); 19.3% compared with 41.7% in the EMLA group. The changes in heart rate were similar in both groups. CONCLUSIONS: We found that glucose is effective in reducing symptoms associated with pain from venipuncture in newborns and seems to be better than the local anesthetic cream EMLA. http://www.pediatrics.org/cgi/content/full/110/6/1053 Deshmukh LS, Udani RH. Analgesic effect of oral glucose in preterm infants during venipuncture--a double-blind, randomized, controlled trial. J Trop Pediatr. 2002 Jun;48(3):138-41. The aim of the present study was to evaluate the effect of different concentrations of glucose on measures of neonatal pain during venipuncture. A randomized, double-blind, placebo controlled trial was carried out at the neonatal intensive care unit at the King Edward Memorial Hospital. Sixty healthy preterm infants of gestation age 28-37 weeks and postnatal age 2-28 days were randomized to receive 2 ml of one of three solutions (sterile water, 10 per cent wt/vol. glucose and 25 per cent wt/vol. glucose) in the mouth 2 min before venipuncture. There was a significant reduction in duration of first cry in the babies given 25 per cent glucose compared with controls and those given 10 per cent glucose. There was no significant effect on heart rate, respiratory rate or oxygen saturation. It is concluded that concentrated glucose solution seems to reduce pain and may be a useful and safe analgesic for minor procedures in neonates. Anne Marie Frey BSN, RN, CRNI Clinical Nurse Level Four Vascular Access Nurse Specialist: IV Team The Children's Hospital of Philadelphia Leadership Office: room 5057B, CHOP Main 5thFloor Phone: 215-590-4204 or ext. 44204 Beeper: 21826 [EMAIL PROTECTED] >>> "Sarah Kuykendall" <[EMAIL PROTECTED]> 03/10/06 2:47 PM >>> Last night I started a 6-week-old in ER. They'd given her sucrose which they claim calms babies (children?) and reduces pain. She was calm, but also sick so we weren't sure which was the reason. The MD claimed this is a fairly common thing now. Any of you using this? Thanks! Sarah Kuykendall 503-786-8228 [EMAIL PROTECTED] http://www.mail-archive.com/venous%40mailsrv1.ohsu.edu/index.html www.hungersite.com
