We you at INS in Reno or AVA in Indy this year? I gave a
presentation on pathophysiology of 4 common complications, phlebitis
was one. Here is the list of references:
1.
Cheek D, Smith HM,
Good J. New respect for the humble endothelium. Nursing2006.
2006;36(3):44-47.
2.
Palefski S, Stoddard
G. The infusion nurse and patient complication rates of
peripheral-short catheters: A prospective evaluation. Journal of
Intravenous Nursing. 2001;24(2):113-123.
3.
Maki DG, Ringer M.
Risk factors for infusion-related phlebitis with small peripheral
venous catheters. Annals of Internal Medicine. 1991;114:845-854.
4.
Kuwahara T, Asanami
S, Kubo S. Experimental infusion phlebitis: Tolerance osmolality of
peripheral venous endothelial cells. Nutrition.
1998;14(6):496-501.
5.
Kuwahara T, Asanami
S, Tamura T, Kubo S. Dilution is effective in reducing infusion
phlebitis in peripheral parenteral nutrition: An experimental study in
rabbits. Nutrition. 1998;14(2):186-190.
6.
Stranz M. Adjusting
pH and osmolarity levels to fit standards and practices. Journal of
Vascular Access Devices. 2002;7(3):12-18.
7.
Robibaro B, Vorbach
H, Weigel G, et al. Endothelial cell compatibility of glycopeptide
antibiotics for intravenous use. Journal of Antimicrobial
Chemotherapy. 1998;41(297-300).
8.
Armbruster C,
Robibaro B, Griesmacher A, Vorbach H. Endothelial cell compatibility
of trovafloxacin and levofloxacin for intravenous use. Journal of
Antimicrobial Chemotherapy. 2000;45:533-535.
9.
Vorbach H,
Armbruster C, Robibaro B, Griesmacher A. Endothelial cell
compatibility of azithromycin and erythromycin. Journal of
Antimicrobial Chemotherapy. 2002;49:407-409.
10.
Lanbeck P, Odenholt
I, Riesbeck K. Dicloxacillin and erythromycin at high concentrations
increase ICAM-1 _expression_ by endothelial cells: A possible factor in
the pathogenesis of infusion phlebitis. Journal of Antimicrobial
Chemotherapy. 2004;53(2):174-179.
11.
Tagalakis V, Kahn S,
Libman M, Blostein M. The epidemiology of peripheral vein infusion
thrombophlebitis: A critical review. American Journal of Medicine.
2002;113:146-151.
12.
Kagel E, Rayan G.
Intravenous catheter complications in the hand and forearm. Journal of
Trauma. 2004;56:123-127.
13.
Schears G. Summary
of product trials for 10,164 patients: Comparing an intravenous
stabilizing device to tape. Journal of Infusion Nursing.
2006;29(4):225-231.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
Bottom line is that is evidence from animal studies that drug pH
of 4.5 causes severe phlebitis in 100% of cases using veins from
rabbit ears.
Now there is also evidence that chemical phlebitis is real. Human
umbilical veins are used to harvest endothelial cells, cultured in a
lab, then challenged with various antibiotics, then cellular products
of inflammation were measured. Many antibiotics, including vanco,
produce these inflammatory chemicals.
Hope this helps, Lynn
At 5:37 AM -0700 10/27/06, DS BROADHURST wrote:
We are presently in dialogue with pharmacy re central administration of vancomycin and are looking for more evidence to support this. Lynn, we have your 3 articles (thank you!); however pharmacy is requesting further published references. I know many of the esteemed nurses on this list serve have been instrumental in implementing this in your facilities. Would love to know what evidence you presented to facilitate this. If your pharmacy has a parenteral drug manual in which administration of Vanco via CVAD is recommended (or any another reference), could you kindly email or fax a copy to me.
Many thanks,
Daphne Broadhurst, RN
Ottawa ON
fax 613-739-6641
--
Lynn Hadaway, M.Ed., RNC, CRNI
Lynn Hadaway Associates, Inc.
126 Main Street, PO Box 10
Milner, GA 30257
http://www.hadawayassociates.com
office 770-358-7861
Lynn Hadaway Associates, Inc.
126 Main Street, PO Box 10
Milner, GA 30257
http://www.hadawayassociates.com
office 770-358-7861
