How to match A but not B

[howard Schwartz]

I want to match lines that contain the word, DEBIT but do not contain the 
word PPD. How to I construct a pattern that will do this?

For example the pattern should exclude a line like,
        DEBIT, this is a line with PPD in it


But the pattern should match:

        DEBIT, this is a line without a certain word in it.

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