It seems someone has encountered the same problem before:
http://www.mail-archive.com/vmtk-users@lists.sourceforge.net/msg00283.html

I followed Luca's suggestions apply smoothing (tried passband of 0.01 and
0.1) and add a subdivision step before vmtkcenterlines. Still no luck,
vmtkcenterlines script will never return. Any suggestions?

On Tue, Aug 6, 2013 at 9:23 PM, Xiaoli Zhang <zhang...@gmail.com> wrote:

> I am new to vmtk and I am trying to extract centerline from CT image of
> the aorta. I prepared the surface in Amira and save as stl (ASCII) format.
> Then I ran vmtkcenterlines script and place a source point at inlet and a
> target point at outlet. vmtk then show "computing centerline" and staying
> for a very long time (>12 hours). The surface I am working on is a small
> file (stl size <1MB).
>
> Anyone can help please? I can send the screenshot of the surface and stl
> file if needed. Thanks.
>
> Xiaoli
>
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