2016-04-09 15:55 GMT-06:00 Zidan Zhang <[email protected]>:
> Dear Christoph
> Thank you so much for the answer, I will try it.
> I have two further questinos:
> 1. Does the mapping scheme influence the IBI iterations? When I separate -OH
> and -C6H4 as two beads (there are other beads like -(CH2)4 and -COOH), the
> system may crash during the MD, and I need a very small time step to keep
> the MD run stable (0.00002 ps), but when I treat -OH and -C6H4 as one bead,
> everything is fine (time step is 0.002 ps);
Yes, the mapping can make a huge difference in the interactions and hence IBI.
There was an interesting paper about the influence of mappings:
<http://scitation.aip.org/content/aip/journal/jcp/136/19/10.1063/1.4705420>

> 2. Can I just ignore the improper dihedral, and using only bond, angle and
> nonbonded interactions, are they enough to maintain the structure as its
> target atomistic structure? All the interactions are tabulated. (I have
> checked the distributions of impropers during the iteration, the peak
> positions are the same to the target distributions, but the peak intensities
> are different.)
This really depends on your system. But I would start with trying to
separate bonded and non-bonded interactions.(see the 2009 Votca
paper).
Do a single chain in vacuum simulation, take the bonded distributions
from there Boltzmann invert them and just do IBI on the non-bonded
interactions while keep the bonded ones fixed. You can always do IBI
on the bonded interaction at a later stage as well if the
distributions aren't reproduces good enough.

Christoph
> Best regards,
> Zidan
>
> On Saturday, April 9, 2016 at 11:26:38 PM UTC+2, Christoph Junghans wrote:
>>
>> 2016-04-09 15:02 GMT-06:00 Zidan Zhang <[email protected]>:
>> > Dear all,
>> > As mentioned in the title, does Votca support improper dihedrals in IBI
>> > method? I have checked the manual, but found no answer.
>> > When I include improper dihedrals into my system, the simulation box
>> > always
>> > explode, the error message is general for GROMACS: "4 of the 14000
>> > bonded
>> > interactions could not be calculated because some atoms involved moved
>> > further apart than the multi-body cut-off distance (1.20727 nm) or the
>> > two-body cut-off distance (1.5 nm)".
>> > But when I ignore the improper dihedrals, everything is OK for the IBI
>> > iterations.
>> Technically nothing prevents you from using improper dihedrals in
>> VOTCA, but the above error looks like
>> there is a problem in your setup. Before doing IBI you need to ensure
>> that your setup works, you can do so by replacing the missing
>> interaction by normal LJ ones and run it for a couple of hundred
>> steps.
>> Once you have a set of LJ interaction, which don't make your system
>> explode, you can use these as initial guesses in IBI.
>>
>> Christoph
>>
>> > Thank you very much!
>> > Zidan Zhang
>> >
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>>
>>
>> --
>> Christoph Junghans
>> Web: http://www.compphys.de
>
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-- 
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Web: http://www.compphys.de

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