I don't think anyone is comparing web2py to .net (thank goodness). A better comparison is Ruby on Rails and Massimo is a bit like DHH. I get the impression that he is pretty passionate about web2py and his position at the university would enable him to continue working on it for awhile. And if that doesn't happen, hey, it's open source and anyone can pick it up.
What we're missing is something like the 37signals product suite to push the framework in real world use. Is anyone here working on a public web site that might scale up? I'm about to give it a shot. The risk seems manageable. I've never really heard of anyone actually being unable to scale a popular service. The problem is usually the opposite: premature optimization.
