Two Arg side chains stack next to each other in ferritin and in GST (see, for example, Arg-59 and its symmetry mate in 3F33). I expect there are other examples, but these two come readily to mind.
Cheers, Pat On 27 Mar 2014, at 7:11 PM, Tom Peat wrote: > Hello All, > > I am appealing to the community as I don't seem to be able to find through > Google what I am looking for, and I just don't have the ability to look > through every structure in the PDB to find this. > I have what I think is an interesting case: a two domain protein structure > with a mostly hydrophobic interface between the two domains- the kicker is > that I have two charged residues buried in this domain and they are > identical. > That is, I'm looking for an Arg-Arg or Asp-Asp type interaction (not Arg-Asp) > where these residues are less than 4 Angstroms apart. So I was wondering if > anyone had seen this in any other structure(s)? > The really interesting bit is that this interaction actually regulates the > activity of the enzyme domain although the domain interface isn't that close > to the catalytic site. > > Thanks in advance to all those who can find a reference to this kind of > interaction. > Cheers, tom --------------------------------------------------------------------------------------- Patrick J. Loll, Ph. D. Professor of Biochemistry & Molecular Biology Director, Biochemistry Graduate Program Drexel University College of Medicine Room 10-102 New College Building 245 N. 15th St., Mailstop 497 Philadelphia, PA 19102-1192 USA (215) 762-7706 pjl...@gmail.com pl...@drexelmed.edu
