Still sounds more like a transfusion reaction than anything with the meds. Hang in there. See what the afternoon labs show.
Amani From: Felvtalk <felvtalk-boun...@felineleukemia.org> On Behalf Of Patricia Oliveira Sent: June 7, 2019 1:44 PM To: felvtalk@felineleukemia.org Subject: Re: [Felvtalk] Rescued kitten felv + Hi, Amani Nori is receiving doxy+prenisolone+stanazolol even in the hospital. I know it can be a reaction but i thought higher dose of prednisolone would prevent hemolysis. I also know it's normal for part of the red blood cells to be cleared right after the transfusion, but i don´t remember if it was icteric plasma on last one. I was hopefull she would come back home tomorrow, now i don´t know if it will be possible. Today she must have am echocardiogram too because x-ray showed an enlarged heart. Thank you! Em sex, 7 de jun de 2019 às 14:18, Amani Oakley <aoak...@oakleylegal.com<mailto:aoak...@oakleylegal.com>> escreveu: Hi Patricia The Stanozolol often has a side-effect of elevating liver enzymes, though I cannot remember if it also increased bilirubin (which would be what would cause the icteric observation of the plasma). However, hang in there. If it is the Stanozolol, my experience is that the liver enzymes drop right back to normal, shortly after it is discontinued, and there is no lasting damage to the liver. For now, what you have described (low temp and slightly lower heart rate) seems more likely to be related to the transfusion itself, rather than anything else going on. It is also possible that with the additional transfusion, there is a higher than normal red cell destruction going on, which would be another explanation for the increased icterus in the blood (which will also show as an increase in bilirubin). Elevated bilirubin can often be caused by a reaction to a blood transfusion. If the high bilirubin is the indirect or the unconjugated portion, it is related to red cell break down. The direct bilirubin (conjugated portion) is related to liver function. The lab results are usually broken down to Total bilirubin and Direct bilirubin. The indirect portion is obtained by subtracting the direct amount from the total amount. I myself went through the pressure of the vets wanting me to discontinue the Stanozolol because of abnormal liver enzymes. My logic was that there was nothing else. If I discontinued the Stanozolol, my cat would die, period. I continued and found that in the end, the liver enzymes normalized on their own, even though I had Zander on almost continuous Stanozolol for close to two years. I know that you know that you are only temporarily helping Nori with blood transfusions, and the virus is still attacking cells, etc. In my opinion – and mine alone – my experience and research leads me to the conclusion that the combination of Doxycycline/Prednisone/Stanozolol worked to not only boost the red cell production, but I believe that the Doxycyline assisted in keeping the viruses from properly reproducing. However, anticipate that when the vet gets back the second set of blood work, she may well try to tell you to discontinue the Stanozolol. Amani From: Felvtalk <felvtalk-boun...@felineleukemia.org<mailto:felvtalk-boun...@felineleukemia.org>> On Behalf Of Patricia Oliveira Sent: June 7, 2019 12:53 PM To: felvtalk@felineleukemia.org<mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] Rescued kitten felv + Hi, Amani! Nori got another transfusion last night, hematocrit was 11.9 before it. Today morning, i talk to the hospital's veterinarian, she said hematocrit went to 29 and Nori was fine, all normal parameters and eating by herself again. But plasma was intensely icteric. I think this means red cells being destroyed, isn't it? About one hour ago, veterinarian said Nori was with low temperature and heart rate slightly lower than normal. She was waiting the new blood work. In the morning, it was done only hematocrit, not complete blood work. i am worried again. Thank you, Patrícia Em ter, 4 de jun de 2019 às 23:46, Amani Oakley <aoak...@oakleylegal.com<mailto:aoak...@oakleylegal.com>> escreveu: I would be leery of the going the route suggested by the vet at this juncture. I seriously seriously doubt if the erythropoietin will help. See my earlier where I explain why. Amani From: Felvtalk <felvtalk-boun...@felineleukemia.org<mailto:felvtalk-boun...@felineleukemia.org>> On Behalf Of Patricia Oliveira Sent: June 4, 2019 8:53 PM To: felvtalk@felineleukemia.org<mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] Rescued kitten felv + Hi, Lorraine Veterinary wants to increase prednisolone to immunosuppressive dose and add erythropoietin. She thinks it is immune-mediated anemia and not mycoplasma. Nori is receiving 1,2 mg prednisolone, twice a day. She weighs only 1 kg. We did x-ray today too. No visible tumor but we found a possible cardiopathy ("Increased globular-looking heart silhouette"). :( Em ter, 4 de jun de 2019 às 20:50, Lorraine Johnston <johnston1...@comcast.net<mailto:johnston1...@comcast.net>> escreveu: Patricia, I would go with the transfusion and also start erythropoietin. Stanozolol is supposed to stimulate erythropoietin production, but she might need a boost of the ready-made drug just to keep her alive until then. - Lorraine "Sometimes it is the people no one can imagine anything of who do the things no one can imagine." - Alan Turing From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org<mailto:felvtalk-boun...@felineleukemia.org>] On Behalf Of Patricia Oliveira Sent: Tuesday, June 4, 2019 6:34 PM To: felvtalk@felineleukemia.org<mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] Rescued kitten felv + Hi, We did another blood work today, her hematocrit is 13% now :( She is very sleepy but responsive when i talk to her. I don´t know if i can wait some more days to see if stanozolol is working. Or maybe it would be better get another transfusion right now. Today, vet talk about erythropoietin. Do you know if it can be used with stanozolol? Thank you, Patrícia Em sáb, 1 de jun de 2019 às 14:44, Amani Oakley <aoak...@oakleylegal.com<mailto:aoak...@oakleylegal.com>> escreveu: Hi Patricia – I gave all the pills together, morning and evening, except for the metoclopramide which was given ½ or so before meals. The rest I gave with the meals. I didn’t observe a problem with giving them together. You might also try baby food to get Nori to eat. Get the pureed kind (beef or chicken with or without vegetables), so it can be sucked up into a syringe. If my Zander wasn’t eating (and he wasn’t at the start of the medication regime), then I would use a syringe to get the baby food into him. Baby food is easy to digest and has good things in it. I would target – say – five 3 cc syringe-fulls at each feeding. I would boost the number of syringe-fulls if possible. Eventually, Zander started eating the baby food on his own, and then I graduated to moist food, and really, anything he wanted until he put the weight back on. I had a look at the picture you sent and Nori is adorable. I am crossing my fingers for you and for Nori. Keep us updated on her progress. Amani From: Felvtalk <felvtalk-boun...@felineleukemia.org<mailto:felvtalk-boun...@felineleukemia.org>> On Behalf Of Patricia Oliveira Sent: June 1, 2019 12:36 PM To: felvtalk@felineleukemia.org<mailto:felvtalk@felineleukemia.org> Subject: Re: [Felvtalk] Rescued kitten felv + Hi, Amani! Thanky you very much for you email! Nori was discharged from the hospital yesterday night. She is eating baby dry food. I tried canned but she didn´t accept so weel. Today i bought other kinds of canned, i'll try them hoping she likes some one. Compound pharmacy must delivery stanozolol today. Are there any precautions regarding medication schedules? Close or far to doxy, for example? This is Nori: https://catsnecropolis.blogspot.com/2019/06/nori-teve-alta.html<https://catsnecropolis.blogspot.com/2019/06/nori-teve-alta.html?fbclid=IwAR0cXMedtfi73B81pJI7QiYGwRTJf9VJp-JN7S_Tstb0ANeg0Hm4ObtFH_A> Thank you! Patrícia Em qui, 30 de mai de 2019 às 20:52, Amani Oakley <aoak...@oakleylegal.com<mailto:aoak...@oakleylegal.com>> escreveu: Sorry Patricia – after going on and on in my last email, I realized I hadn’t actually answered your question. I think you can probably use the stanozolol with the Doxycycline, without the prednisone, but prednisone itself has properties which help to boost red cell production. Try it out, keep close tabs on the haematology results and see if you are getting a good response on just Doxycycline and the Stanozolol. If not, add the prednisone. You may find that this combination assists with the FIP as well, as per my previous email. Amani From: Felvtalk <felvtalk-boun...@felineleukemia.org<mailto:felvtalk-boun...@felineleukemia.org>> On Behalf Of Patricia Oliveira Sent: May 30, 2019 12:56 PM To: felvtalk@felineleukemia.org<mailto:felvtalk@felineleukemia.org> Subject: [Felvtalk] Rescued kitten felv + Hi from Brazil, I rescued a very weak, dehydrated, extremely thin kitten. She's hospitalized now. Her hematocrit was 8, had blood transfusion which raised hematocrit to 22, now it is 19. Low reticulocyte count. She has difficulty walking, which we can not define if it is just weakness or neurological. Already had a seizure. She also have changes in her kidneys. It has been tested and is felv + She is receiving doxy and the hospital vets would like to include prednisolone. However, as it is not possible yet to rule out PIF, and the medication I could use in the case of PIF does not work if the cat received prednisolone, I am trying to avoid it. The veterinarian agreed to prescribe stanozolol. Can it be used without prednisolone, only with doxy she is already receiving? Thank you! 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