Hi Toufigh,
R has updated its memory handling in recent updates, so if you are using an older version of R then updating to the latest version may help. Otherwise you might try subsetting the plot to reduce the number of plots created. For example: # Change the covariate scope change.xvardef(xpdb,var="covariates") <- c("SEX","AGE","WT") # then run the plot again: parm.vs.cov(xpdb) The scope can also be changed in the classic menu system. Best regards Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 <http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/> www.farmbio.uu.se/research/researchgroups/pharmacometrics/ From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Toufigh Gordi Sent: den 13 januari 2012 09:29 To: nmusers@globomaxnm.com Subject: [NMusers] Memory problems with Xpose Hi, I am trying to plot model parameters vs. covariates suing Xpose. The data file is rather large and I get the following message: In initialize(value, ...) : Reached total allocation of 1535Mb: see help(memory.size) 2: In initialize(value, ...) : Reached total allocation of 1535Mb: see help(memory.size) Error in print(parm.vs.cov(.cur.db)) : error in evaluating the argument 'x' in selecting a method for function 'print': Error: cannot allocate vector of size 171 Kb Can anybody offer a remedy? Thanks! Toufigh