Salvador Espada Hinojosa --

The problem, of course, is that a random substitution on an interior
branch of a tree increases or decreases the size of more than one
distance in the distance matrix.  The distances aren't independent in
their statistical noise.  So you can't just sample distances after the
distance matrix is computed.

Joe Felsenstein
 Department of Genome Sciences and Department of Biology,
 University of Washington, Box 355065, Seattle, WA 98195-5065 USA

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