SCIENCE-JOBS-DE Stellenausschreibung (vacancies) ----------------------------------------------------------------------
We are interested in elucidating the role of multifunctional proteins like CSB, WRN and TFIIH in RNA polymerase I transcription. Mutations in these proteins are followed by premature aging diseases like Cockayne syndrome, Werner syndrome and trichothiodystrophy. The critical function of these proteins, preventing us from accelerated aging, still remains to be identified, and we are asking if basal transcription mechanisms, in particular RNA polymerase I transcription, are involved in the pathogenesis of these diseases. We were able to show that TFIIH plays an essential role in RNA polymerase I transcription (Iben et al, 2002). In the current project we are trying to define the molecular function of TFIIH in RNA polymerase I transcription and are interested in premature-aging causing diseases in TFIIH and their consequences for rDNA transcription. We want to investigate how disturbances in rDNA transcription are transduced to the cell. Following the concept of the nucleolus as a stress-sensor of the cell we are asking the question if reduced rDNA transcription alters cellular stress sensitivity and thus contributes to the elevated stress-sensitivity of cells from premature-aging diseases. We are a small group and part of the Department of Dermatology and Allergology of the University of Ulm and we work mainly with protein-biochemical, cell biological and molecular biological methods. If you are interested in working with intensive mentoring in a stimulating environment please contact us via email. Iben, S., Tschochner, H., Bier, M., Hoogstraten, D., Hozak, P., Egly, J.M., and Grummt, I. (2002) TFIIH plays an essential role in RNA polymerase I transcription. Cell. 109, 297-306 Bradsher, J., Auriol, J., Proietti de Santis, L., Iben, S., Vonesch, J.L., Grummt, I., and Egly, J.M. (2002). CSB is a component of RNA pol I transcription. Mol Cell. 10, 819- Lebedev A, Scharffetter-Kochanek K, Iben S (2008) Truncated Cockayne syndrome B protein represses elongation by RNA polymerase I. J Mol Biol. 382, 266-274 Lutomska A, Lebedev A, Scharffetter-Kochanek K, Iben S (2008) The transcriptional response to distinct growth factors is impaired in Werner syndrome cells. Exp Gerontol. 43,820-826 ---------------------------------------------------------------- Von: Dr Sebastian Iben sebastian.ibenquni-ulm.de Department of Dermatology, University of Ulm Ulm Ansprechpartner: Dr Sebastian Iben ---------------------------------------------------------------- ---------------------------------------------------------------------- Mehr Informationen zu SCIENCE-JOBS-DE finden Sie im WWW unter der Adresse http://jobs.uni-hd.de, insbesondere zu den Themen An/Abmelden, Informationen fuer Anbieter und "Netiquette" - more information on SCIENCE-JOBS-DE is available on the Web at http://jobs.uni-hd.de, especially regarding subscription and unsubscription, information for offerings and "netiquette".
