SCIENCE-JOBS-DE Stellenausschreibung (vacancies) ----------------------------------------------------------------------
Dieses Angebot wurde eingegeben bei http://www.drarbeit.de, der Internet-Stellenboerse und Kooperationspartner von SCIENCE-JOBS-DE für Diplom- und Promotionsarbeiten ---------------------------------------------------------------------- Fachgebiete: Biologie Thema: Doktorarbeit: Crosstalk between checkpoint signaling in DNA damage & metabolic stress Ansprechpartner: Dr. rer. nat. Thomas Hofmann Antwort an: t.hofm...@dkfz.de Institution: Deutsches Krebsforschungszentrum/ DKFZ-ZMBH Allianz Ort: 69120 Heidelberg, Im Neuenheimer Feld 242 ---------------------------------------------------------------------- Checkpoint signaling plays a crucial role in response to DNA damage and in metabolic disorders. Moreover, the DNA damage signaling and metabolic stress signaling cascades apparently use common signaling molecules. This PhD project is focussed on the molecular crosstalk between the signaling cascades mediating genotoxic stress and metabolic stress. The role of novel candidate stress regulators will be probed using techniques including biochemistry, molecular biology and cell biology. Successful candidates will enter the Helmholtz International Graduate School for Cancer Research and will also have access to the DKFZ-ZMBH Alliance study program. This project is part of a joint project with the group of Dr. S. Herzig (Research group Molecular Metabolic Control, DKFZ). Methoden: A combination of techniques including molecular biology, biochemistry and cell biology will be used (eg. western blotting, RNA interference, in vitro & in vivo interaction analysis, kinase assays, stress induction, confocal microscopy, cell fate analysis) Anfangsdatum: 1. Januar 2010 geschätzte Dauer: 3 Jahre Bezahlung: TVL 13/2 Veröffentlichungen: Bitomsky, N. & T.G. Hofmann (2009).Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2. FEBS J., advance online publication. Sombroek, D. & T.G. Hofmann. (2009). How cells switch HIPK2 on and off. Cell Death & Differentiation 16: 187-94. Winter, M., Sombroek, D., Dauth, I., Moehlenbrink, J., Scheuermann, K., Crone, J. & T.G. Hofmann. (2008). Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. Nature Cell Biol 10: 812-824. Dauth, I., Krüger, J. & T.G. Hofmann. (2007). HIPK2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM. Cancer Research 67:2274-9. Homepage: http://www.dkfz.de/en/cellular_senescence/index.html The highly motivated candidate should hold a Diploma or Master in Biology or a related field. A strong background in molecular biology or biochemistry is required. Please include a CV, copies of high school exam (eg. Abitur), university exams and contact details of 2 referees along with a cover letter stating your reasons for applying. Please apply online via the following link: http://www.dkfz.de/de/stellenangebote/index.php?id=116/2009 ---------------------------------------------------------------------- Mehr Informationen zu SCIENCE-JOBS-DE finden Sie im WWW unter der Adresse http://jobs.uni-hd.de, insbesondere zu den Themen An/Abmelden, Informationen fuer Anbieter und "Netiquette" - more information on SCIENCE-JOBS-DE is available on the Web at http://jobs.uni-hd.de, especially regarding subscription and unsubscription, information for offerings and "netiquette".
