Hi,
I would like to find a bioinformatic tool that will allow me to predict the
dimerisation interface of a protein.
A structural model has been generated, and it is known to exist as a homo-dimer.
Does anyone know of a suitable program?
Thank you for your help.
Karen
Hey Karen,
Pisa analyzes oligomerization interfaces.
http://www.ebi.ac.uk/msd-srv/prot_int/pistart.html
Andreas
karen yates wrote:
Hi,
I would like to find a bioinformatic tool that will allow me to predict the
dimerisation interface of a protein.
A structural model has been generated,
HADDOCK..?
protein-protein docking..
Dominguez et al., 2003, JACS, 125, 1731-1737
Kristof
On 29 Nov 2007, at 13:22, karen yates wrote:
Hi,
I would like to find a bioinformatic tool that will allow me to
predict the
dimerisation interface of a protein.
A structural model has been
PISA gives a good analysis of a known interface, but won't predict it
from scratch. So basically you need a protein-protein docking program of
which there are several:
3DDock, gramm, zdock, etc, etc
There's a review in G.R.Smith and MJE Sternberg, Curr Opion Struct Biol,
12, 28 (2002) -
Karen,
MolSoft offers a free online tool that predicts protein-protein
interfaces using our ICM software.
http://www.molsoft.com/oda.cgi
more information here:
http://www.molsoft.com/oda.html
Fernandez-Recio, J., Totrov, M., Skorodumov, C., Abagyan, R.Optimal
Docking Area: A New Method for
