[ccp4bb] Postdoc position to study membrane protein structure

[Zheng, Lei]

Postdoctoral Position at University of Texas McGovern Medical School at Houston
A postdoctoral position is available in the Department of Biochemistry and 
Molecular Biology at University of Texas McGovern Medical School in the 
laboratory of Dr. Lei Zheng to study the structure and regulatory mechanism of 
mammalian sodium/calcium exchanger proteins using X-ray crystallography and 
cryo-electron microscopy.
Sodium/calcium exchanger proteins are involved in maintaining Ca2+ homeostasis 
in most mammalian tissues and play essential roles in cardiac 
contraction-relaxation and neuronal transmission.  The successful candidate 
will perform protein expression and purification using insect cell systems, and 
use cryo-electron microscopy and single particle analysis approaches to study 
the structure of exchanger complex with small drug inhibitors. The fellow will 
also use X-ray crystallography and other biochemical approaches to study a 
novel regulatory mechanism of exchangers mediated by accessory proteins newly 
identified in our lab.
The ideal candidate should have a recent Ph.D. in Structural Biology and 
Biochemistry with demonstrated experience in protein expression, purification 
and characterization. Experience with membrane protein and insect cell culture 
will be a great asset.  The fellow will have an opportunity to work other 
groups in the department to learn cryo-Electron Microcopy.

The laboratory is located in Texas Medical Center, the largest campus for 
medical research in the world, which provides outstanding environments for 
academic development.  Houston is a highly culture-diversified city with 
affordable living costs. Salary will be based on NIH standard and individual 
experience.

Interested applicants should send their CV and three letters of reference to 
Dr. Lei Zheng (lei.zh...@uth.tmc,edu).


Lei Zheng, Ph.D.
Associate Professor
Center for Membrane Biology
Department of Biochemistry and Molecular Biology
University of Texas McGovern Medical School
6431 Fannin Street, MSB 6.218 (office), 6.408 (lab)
Houston, TX 77030
Tel: 713-500-6083 (office), -7451 (lab)



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

[ccp4bb] Postdoctoral Position at Exeter University

[Littlechild, Jennifer]

A postdoctoral position is available on a multidisciplinary project between the 
group of Prof Littlechild at the Henry Wellcome Building for Biocatalysis and 
Prof Frank Volmer in Physics within the new LSI Building in association with 
the Physics Department. The aim is  to study enzyme structure, stability and 
mechanism, and enzyme folding with state-of the art methodologies including 
single-molecule optical nanosensors, X-rays, and molecular dynamics 
simulations. This project will be part of the UKRI Molecular Mechanics 
Initiative at the University of Exeter which is a cutting-edge research 
programme that aims to achieve breakthroughs in how to detect, analyse, and 
manipulate molecules at the ultimate single-molecule level.
Experience with gene cloning and over-expression, enzyme purification, X-ray 
structural analysis, mutational analysis and application of other biophysical 
techniques is required. Familiarity with surface immobilisation of proteins and 
enzymes, molecular dynamics simulations, Raman and SERS protein analysis, and 
electrochemical sensors is desirable.
The successful candidate can be appointed as Postdoctoral Research Fellow 
(Grade F) depending on the skills and experience the individual can bring to 
the role.
Postdoctoral Research Fellow on Grade F from £35,211 up to £39,609 per annum. 
Please find further job specifications on the Exeter web site and any 
interested candidates should apply by the closing date of 28th May. For further 
information, please contact Prof J Littlechild, email 
j.a.littlech...@exeter.ac.uk, or telephone (01392) 7223468.







To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

Re: [ccp4bb] Where is M.Harding's website for metal coordination geometry

[Min, Xiaoshan]

Thanks to all who responded for the suggestions.  Here are the summaries for 
access to the original website and alternative servers:

  1.  Web archive:  
http://web.archive.org/
  
(http://web.archive.org/web/20161031170012/http://tanna.bch.ed.ac.uk/
 )
  2.  MetalPDB: 
http://metalweb.cerm.unifi.it
  3.  Check my metal: 
https://csgid.org/metal_sites
  4.  Zip archive from Acta Cryst.D (open access)  
https://urldefense.proofpoint.com/v2/url?u=https-3A__doi.org_10.1107_S0907444904004081=DwID-g=Sexio4usKrYWFsrnxgjbcQ=4qhth_Y1zobUlbkWOn8dUA=VLKn1ATp4o-zt7x44R5SZXAnPNAuQujLE4Y3B1spFXc=8REgaccG0Wo9FJGz-EkKzm6-4xEtL2nBIMo_vkQ9MXE=


Xiaoshan


From: "CCP4BB@JISCMAIL.AC.UK"  on behalf of "Schnicker, 
Nicholas J" 
Reply-To: "Schnicker, Nicholas J" 
Date: Tuesday, May 7, 2019 at 6:39 AM
To: "CCP4BB@JISCMAIL.AC.UK" 
Subject: [External] Re: [ccp4bb] Where is M.Harding's website for metal 
coordination geometry

Hi all,

You can find archives for websites from 
http://web.archive.org/

Here is a link to Harding’s site from 2016  
http://web.archive.org/web/20161031170012/http://tanna.bch.ed.ac.uk/

Xiaoshan- Depending on what you are looking for, I would have a look at 
MetalPDB as others have suggested as they have some nice search features.

Cheers,
Nick

From: CCP4 bulletin board  on behalf of David Briggs 

Reply-To: David Briggs 
Date: Tuesday, May 7, 2019 at 5:17 AM
To: "CCP4BB@JISCMAIL.AC.UK" 
Subject: Re: [ccp4bb] Where is M.Harding's website for metal coordination 
geometry

In addition to MetalPDB there is also Check My Metal.

https://csgid.org/metal_sites

HTH,

Dave




From: CCP4 bulletin board  on behalf of Eleanor Dodson 
<176a9d5ebad7-dmarc-requ...@jiscmail.ac.uk>
Sent: 07 May 2019 10:51
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] Where is M.Harding's website for metal coordination 
geometry

Could CCP4 documentation include a link to both Marjories one and the MetalPDB
http://metalweb.cerm.unifi.it


Eleanor

On Tue, 7 May 2019 at 08:42, Louise Jones mailto:l...@iucr.org>> 
wrote:
Dear All

The supporting information for Marjorie's article published in Acta
Cryst. D in 2004 contains a pdf and a zip archive of the website.

The architecture of metal coordination groups in proteins, Acta Cryst.
D60, 849-859, 
https://doi.org/10.1107/S0907444904004081

Best wishes
Louise



On 

[ccp4bb] Postdoctoral Position at Rutgers University

[Nilgun Tumer]

Postdoctoral Position at Rutgers University



A postdoctoral position is available at the Department of Plant Biology at 
Rutgers University in the laboratory of Dr. Nilgun E. Tumer for an NIH funded 
collaborative project with the Institute for Quantitative Biomedicine to 
identify small molecule and peptide inhibitors against Shiga toxin 2 (Stx2). 
Shiga toxin (Stx) producing E. coli (STEC) and Shigella are foodborne pathogens 
that cause diarrheal disease in millions of people around the world. They 
remain a major challenge for food safety and public health because there are no 
specific therapeutics or vaccines against infection by bacteria producing Shiga 
toxins.



Stxs depurinate the sarcin/ricin loop of the large rRNA and inhibit 
translation. E. coli strains producing Stx2 are associated with more severe 
disease than strains producing Shiga toxin 1 (Stx1). We showed that the A1 
subunit of Stx2 has higher affinity for ribosomes and higher catalytic activity 
than the A1 subunit Stx1 (Basu, D. et al., 2016, Infect. Immun. 84:149-161) and 
identified the residues critical for ribosome binding (Basu, D. et al., 2016, 
Infect. Immun. 84:3290-3301).  Our goal is to develop inhibitors that disrupt 
the activity of Stx2 by inhibiting its interaction with the ribosome. We have 
used surface plasmon resonance-based fragment screening to identify fragments 
that bind to Stx2.


The successful candidate will perform protein expression and purification using 
bacterial systems and will perform X-ray crystallography of inhibitors bound 
Stx2 to help optimize them into more potent leads. Phage display will also be 
used to identify peptides that bind to Stx2. The Stx2 inhibitory activity of 
these peptides will be investigated in cell-free and cell-based assays.

The ideal candidate should have a Ph.D. in Structural Biology and Biochemistry 
and experience in protein expression, purification and characterization, and 
crystallization, and X-ray crystallographic structure determination and 
refinement, and be interested in developing skills in phage display and 
learning cryo-Electron Microcopy, which will be carried out in collaboration 
with the Institute for Quantitative Biomedicine at Rutgers.


Interested applicants should apply online through the ROCS system of Rutgers 
University and in addition send their CV and three letters of reference to Dr. 
Nilgun E. Tumer (tu...@sebs.rutgers.edu) and Dr. 
Xiao-Ping Li (x...@sebs.rutgers.edu).

Information on Dr. Tumer's research can be found at: 
https://plantbiology.rutgers.edu/faculty/tumer/Nilgun_Tumer.html
Contact:  Nilgun Tumer, Department of Plant Biology, SEBS, Rutgers University, 
Foran Hall, 59 Dudley Road, New Brunswick, NJ 08901-8520.  Tel: 848-932-6359.


Dr. Nilgun Tumer
Distinguished Professor
Director, SEBS Core Facility
Department of Plant Biology
SEBS, Rutgers University
59 Dudley Road
New Brunswick, NJ 08901-8520
Tel: 848-932-6359




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

Re: [ccp4bb] Where is M.Harding's website for metal coordination geometry

[Schnicker, Nicholas J]

Hi all,

You can find archives for websites from http://web.archive.org/

Here is a link to Harding’s site from 2016  
http://web.archive.org/web/20161031170012/http://tanna.bch.ed.ac.uk/

Xiaoshan- Depending on what you are looking for, I would have a look at 
MetalPDB as others have suggested as they have some nice search features.

Cheers,
Nick

From: CCP4 bulletin board  on behalf of David Briggs 

Reply-To: David Briggs 
Date: Tuesday, May 7, 2019 at 5:17 AM
To: "CCP4BB@JISCMAIL.AC.UK" 
Subject: Re: [ccp4bb] Where is M.Harding's website for metal coordination 
geometry

In addition to MetalPDB there is also Check My Metal.

https://csgid.org/metal_sites

HTH,

Dave




From: CCP4 bulletin board  on behalf of Eleanor Dodson 
<176a9d5ebad7-dmarc-requ...@jiscmail.ac.uk>
Sent: 07 May 2019 10:51
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] Where is M.Harding's website for metal coordination 
geometry

Could CCP4 documentation include a link to both Marjories one and the MetalPDB
http://metalweb.cerm.unifi.it


Eleanor

On Tue, 7 May 2019 at 08:42, Louise Jones mailto:l...@iucr.org>> 
wrote:
Dear All

The supporting information for Marjorie's article published in Acta
Cryst. D in 2004 contains a pdf and a zip archive of the website.

The architecture of metal coordination groups in proteins, Acta Cryst.
D60, 849-859, 
https://doi.org/10.1107/S0907444904004081

Best wishes
Louise



On 07/05/2019 00:27, Min, Xiaoshan wrote:
> Hi
>
> I am trying to find out if the website metal coordination groups in
> proteins 
> >
>  is still accessible.   After some
> google search, I still can’t find it except this ccp4 newsletter
> http://www.ccp4.ac.uk/newsletters/newsletter40/15_metal_coord.html
>  .   I
> trust that someone in this list might help me  find an alternative.
>
> Thanks,
>
> Xiaoshan
>
>
> 
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
>



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

The Francis Crick Institute Limited is a registered charity in England and 
Wales no. 1140062 and a company registered in England and Wales no. 06885462, 
with its registered office at 1 Midland Road London NW1 1AT



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1



To unsubscribe from the CCP4BB list, click the following 

[ccp4bb] IBS/Grenoble: postdoc and PhD openings in time-resolved crystallography at XFELs and synchrotrons

[martin weik]

We have immediate openings for two postdoctoral researchers and one PhD 
student at the /Institut de Biologie Structurale/ (www.ibs.fr 
) in Grenoble, France, to study the structural 
dynamics of light-sensitive proteins by time-resolved serial 
crystallography at XFELs and potentially future 4^th generation 
synchrotrons.


Serial femtosecond crystallography (SFX) at X-ray free electron lasers 
(XFEL) allows studying the structural dynamics of crystalline proteins 
by means of time-resolved crystallography (TR-SFX). We apply TR-SFX to 
explore conformational changes after photon absorption by various 
light-sensitive proteins on a broad time scale ranging from 
sub-picoseconds to seconds (Nature Chemistry 10, 31 (2018)). These 
animate structures obtained by static SFX (J Phys Chem Lett 7, 882 
(2016); Nature 539, 43 (2016).


At the postdoctoral level, we are looking for highly motivated 
individuals with a proven record in macromolecular crystallography with 
a keen interest in data processing and handling and intermediate-state 
structure refinement.


At the PhD level, we welcome applications from students trained in 
protein biophysics, and preferably in crystallography.


If you are interested, please contact either Martin Weik (w...@ibs.fr 
) or Jacques-Philippe Colletier (collet...@ibs.fr).


--

Martin Weik
Structural Protein Dynamics Research Team
Institut de Biologie Structurale
CAMPUS EPN
71 avenue des Martyrs
CS10090
38044 Grenoble Cedex 9; France  

Phone:(33) 4 57 42 85 80


email:  w...@ibs.fr
http://www.ibs.fr/groups/dynamics-and-kinetics-of-molecular/structural-protein-dynamics/?lang=en




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

[ccp4bb] Position Available at Evotec

[Paul McEwan]

Dear All,
an opening is available within our structural biology team. Please see the 
advertisement below and apply through our website if you are interested as 
described at the base of the advert.

Best Wishes,
Paul.. 

Evotec is a leader in the discovery and development of novel small molecule 
drugs with operational sites in Europe and the US. The Company has built 
substantial drug discovery expertise and an industrialised platform that can 
drive new innovative small molecule compounds into the clinic. In addition, 
Evotec has built a deep internal knowledge base in the treatment of diseases 
related to neuroscience, pain, oncology, inflammation and metabolic diseases. 
Leveraging these skills and expertise the Company intends to develop 
best-in-class differentiated therapeutics and deliver superior science-driven 
discovery alliances with pharmaceutical and biotechnology companies. 

We are looking for a highly motivated individual for our Abingdon site to work 
as a

Scientist/Senior Purification Scientist, Structural Biology

Evotec (UK) Ltd is currently seeking to add to our Structural Biology 
Department.  The group works closely with our Discovery Chemistry Department 
and with clients to develop novel small molecule drugs.  The group is at the 
forefront of new science and technology, and is seeking to expand as business 
needs grow. 

Required Knowledge, Skills and Abilities:
•   Extensive knowledge of protein purification, demonstrated through the 
delivery of innovative solutions for drug discovery programs
•   A working knowledge and practical experience with AKTA systems will be 
highly advantageous
•   The successful candidate will have experience working in 
multi-disciplinary teams
•   Experience collaborating with scientists in external organisations 
would be an advantage

Responsibilities may include:
•   Supporting a project team by conducting experiments with defined, 
agreed objectives and timelines
•   Contributing to the design, execution and interpretation of experiments 
in a project team to accomplish project goals
•   Adapting scientific knowledge to resolve problems encountered in 
achieving defined goals with assistance from line manager or other team members 
to meet internal and project deadlines
•   Preparing reports of findings, presenting data, and collaborating with 
other scientists at Evotec
•   Presenting own work at project technical meetings, and department 
technical meetings when required
•   Demonstrating full command of all techniques and tools required for 
assigned responsibilities within the given project
•   Ensuring safe working practices of themselves and any direct reports
•   Complying fully with the company safety policy (including COPs and 
SOPs) when performing experiments
•   Reading scientific literature relevant to the project
•   Adhering to Lab Notebook guidelines regarding accurate documentation of 
lab experiments

Desirable Knowledge, Skills and Abilities:
•   Self-motivated, enthusiastic, cooperative and reliable
•   Knowledge of basic laboratory techniques, and understanding of the 
science underlying the techniques and experiments
•   Experience of working in a lab environment
•   The ability to adapt to changing demands whilst operating under 
pressure to deadlines
•   The ability to work accurately and with attention to detail
•   Good interpersonal skills and the ability to work well with other 
scientific staff
•   The ability to work well independently, and as part of a team
•   Good organisational and time management skills
•   Good verbal communication skills
•   Ability to maintain excellent laboratory records
•   Computer proficiency

Education and Experience:
•   PhD, MSc, BSc degree or equivalent in Biochemistry or related area

If you are interested in this position, please visit Evotec’s Career Page at 
https://recruitment.evotec.com/home.aspx

 
Paul McEwan, Ph.D. 
Principal Scientist, Structural Biology
+44 (0)1235 83 8802  (Direct)
+44 (0)1235 86 3139  (Fax)
paul.mce...@evotec.com 
www.evotec.com  
 
Evotec (UK) Ltd.
114 Innovation Drive,
Milton Park, Abingdon
Oxfordshire OX14 4RZ, UK



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

Re: [ccp4bb] Where is M.Harding's website for metal coordination geometry

[David Briggs]

In addition to MetalPDB there is also Check My Metal.

https://csgid.org/metal_sites

HTH,

Dave




From: CCP4 bulletin board  on behalf of Eleanor Dodson 
<176a9d5ebad7-dmarc-requ...@jiscmail.ac.uk>
Sent: 07 May 2019 10:51
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] Where is M.Harding's website for metal coordination 
geometry

Could CCP4 documentation include a link to both Marjories one and the MetalPDB
http://metalweb.cerm.unifi.it


Eleanor

On Tue, 7 May 2019 at 08:42, Louise Jones mailto:l...@iucr.org>> 
wrote:
Dear All

The supporting information for Marjorie's article published in Acta
Cryst. D in 2004 contains a pdf and a zip archive of the website.

The architecture of metal coordination groups in proteins, Acta Cryst.
D60, 849-859, 
https://doi.org/10.1107/S0907444904004081

Best wishes
Louise



On 07/05/2019 00:27, Min, Xiaoshan wrote:
> Hi
>
> I am trying to find out if the website metal coordination groups in
> proteins 
> >
>  is still accessible.   After some
> google search, I still can’t find it except this ccp4 newsletter
> http://www.ccp4.ac.uk/newsletters/newsletter40/15_metal_coord.html
>  .   I
> trust that someone in this list might help me  find an alternative.
>
> Thanks,
>
> Xiaoshan
>
>
> 
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
>



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

The Francis Crick Institute Limited is a registered charity in England and 
Wales no. 1140062 and a company registered in England and Wales no. 06885462, 
with its registered office at 1 Midland Road London NW1 1AT



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

Re: [ccp4bb] Where is M.Harding's website for metal coordination geometry

[Eleanor Dodson]

Could CCP4 documentation include a link to both Marjories one and the
MetalPDB
http://metalweb.cerm.unifi.it


Eleanor

On Tue, 7 May 2019 at 08:42, Louise Jones  wrote:

> Dear All
>
> The supporting information for Marjorie's article published in Acta
> Cryst. D in 2004 contains a pdf and a zip archive of the website.
>
> The architecture of metal coordination groups in proteins, Acta Cryst.
> D60, 849-859, https://doi.org/10.1107/S0907444904004081
>
> Best wishes
> Louise
>
>
>
> On 07/05/2019 00:27, Min, Xiaoshan wrote:
> > Hi
> >
> > I am trying to find out if the website metal coordination groups in
> > proteins  is still accessible.   After some
> > google search, I still can’t find it except this ccp4 newsletter
> > http://www.ccp4.ac.uk/newsletters/newsletter40/15_metal_coord.html .
>  I
> > trust that someone in this list might help me  find an alternative.
> >
> > Thanks,
> >
> > Xiaoshan
> >
> >
> > 
> >
> > To unsubscribe from the CCP4BB list, click the following link:
> > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
> >
>
> 
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1
>



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

Re: [ccp4bb] Where is M.Harding's website for metal coordination geometry

[Louise Jones]

Dear All

The supporting information for Marjorie's article published in Acta 
Cryst. D in 2004 contains a pdf and a zip archive of the website.


The architecture of metal coordination groups in proteins, Acta Cryst. 
D60, 849-859, https://doi.org/10.1107/S0907444904004081


Best wishes
Louise



On 07/05/2019 00:27, Min, Xiaoshan wrote:

Hi

I am trying to find out if the website metal coordination groups in 
proteins  is still accessible.   After some 
google search, I still can’t find it except this ccp4 newsletter 
http://www.ccp4.ac.uk/newsletters/newsletter40/15_metal_coord.html .   I 
trust that someone in this list might help me  find an alternative.


Thanks,

Xiaoshan




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1





To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

[ccp4bb] 2 postdoctoral fellowships available to study the structure and evolution of viral proteins at Linköping University, Sweden

[Eleonore von Castelmur]

Dear colleagues,

I have two postdoctoral fellowships available in my group.  Please see below 
for the details and feel free to spread it to anyone you think might be 
interested and suitable for the positions.

All the best,
Eleonore


Postdoctoral fellowships to study structural and functional evolution of viral 
proteins
The von Castelmur lab at the Department of Physics, Chemistry and Biology (IFM) 
and part of the Wallenberg Center for Molecular Medicine at Linköping 
University, Sweden, is looking to recruit up to two postdoctoral fellows 
(2-year projects) to study the evolutionary relationship and functional 
repurposing of human proteins acquired by picornaviruses (through horizontal 
gene transfer).
The overall goals of these particular projects are to continue the structural 
and functional characterisation, already begun in the lab. The projects will 
involve molecular biology, biochemistry and biophysics in combination with 
structural biology techniques (in house access to a variety of techniques 
through ProLinC https://liu.se/en/research/prolinc). Therefore, we seek highly 
motivated individuals with practical experience and expertise in cloning and 
protein production (expression, purification, characterization), structural 
biology (experience in at least one technique is required) and an interest in 
learning new methods and skills.

Qualifications and requirements to applicants:


  *   Scholarship may be granted only to non-Swedish citizens with a PhD or 
equivalent acquired in another country than Sweden. The applicant must not have 
been employed by Linköping University previously.
  *   The applicant must have or be about to receive a doctoral degree in a 
subject relevant to the research project (e.g. structural biology, molecular 
biology, biochemistry, biophysics, chemistry, or a related area) and needs to 
be passionate about research. Problem solving ability and creativity are 
essential.
  *   Documented ability to write scientific manuscripts (one or more first 
author papers from Ph.D. and postdoctoral studies will be highly valued)
  *   Excellent English interpersonal, communication and writing skills
  *   Ability to operate both independently but also as a team player in a 
multi-disciplinary environment

Application
The application should consist of the following:
1. A short (maximum 1 A4 page) cover letter, explaining the motivation to 
apply for the position.
2. The CV of the applicant, including a list of published peer-reviewed 
articles.
3. Statement of Research Interests, max 2 pages
4. Copies of the PhD diploma (or equivalent).
5. Contact details for 2-3 references, one of which should be your PhD 
supervisor.
The duration of the fellowship is 2 years. Your application should be written 
in English and prepared as a package in PDF format, to be submitted to 
eleonore.von.castel...@liu.se. Make sure 
to use the subject line: “application for postdoctoral fellowship 
IFM-2019-00239” in the application email. Submit the application on May 21st, 
2019 at the latest. The top ranked candidates will be contacted within three 
weeks from the closing date for an interview. Starting date according to 
agreement. For more information, contact Dr. Eleonore von Castelmur.
Email: eleonore.von.castel...@liu.se
Webpage: https://liu.se/en/employee/elevo74



Eleonore von Castelmur, PhD
Biträdande lektor
Department of Physics, Chemistry and Biology (IFM)
Linkoping University
SE-581 83 Linköping
phone: +46 13 281966
e-mail: eleonore.von.castel...@liu.se




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

[ccp4bb] Open position as PhD in Chemistry with focus on Biophysics

[Magnus Andersson]

We are seeking a PhD student in chemistry that will be part of a research team 
focused on understanding membrane protein transport using experimental 
techniques such as time-resolved X-ray scattering and biochemical assays, as 
well as computer simulation. Application deadline is 2019-06-03.

Project description
Biological membranes contain proteins that are necessary for all forms of Life 
– not least human beings. Development of structural characterization methods 
during the last 20 years has resulted in increased understanding of these 
membrane proteins, which in turn has increased production of new 
pharmaceuticals. We now face a major challenge – how can we take the next step 
and understand how proteins change their structures to perform their designated 
functions. By determining intermediate structures in the natural membrane 
environment, we could significantly increase the number of pharmaceutical 
targets. We will specifically characterize transport proteins in pathogenic 
bacteria, which are absent in humans, since such proteins are targets for 
development of new antibiotics that has potential to fight multi-drug 
resistance that pose a severe threat to humans, society, and health care.

Working tasks
The PhD student will be part of an existing research team that combines 
experimental methods and computer simulation to understand membrane protein 
transport. We have developed a combination of time-resolved X-ray scattering 
and computer simulation capable of determining transient intermediate states in 
the natural membrane environment. Our work is carried out on the absolute 
forefront of structural biology and will prepare the PhD student for a 
continued research career in academia or industry.

The PhD student will acquire a unique skillset with both experimental expertise 
and high-performance computing. The research spans molecular biology production 
and characterization of proteins to development work at the synchrotrons MAXIV 
(Lund) and ESRF (Grenoble). The computer simulations will be performed on the 
national SNIC platform at the high-performance computing center HPC2N. The work 
will be performed within the context of Integrated Structural Biology 
(https://www.biostruct.umu.se) at Umeå University that provides seminar series 
as well as an exciting research environment.

Qualifications
To be admitted for studies at third-cycle level you are required to have 
completed a second-cycle level degree, or completed course requirements of at 
least 240 ECTS credits, of which at least 60 ECTS credits are at second-cycle 
level or have an equivalent education from abroad, or equivalent qualifications.

To fulfill the specific entry requirements to be admitted for studies at 
third-cycle level in chemistry, you are required to have completed first-cycle 
courses of at least 90 ECTS credits within the field of chemistry or another 
subject considered to be directly relevant to the specialization in question 
(such as physics, biology etc). Of those 90 ECTS credits, at least 15 ECTS 
credits shall have been acquired at second-cycle level within the 
specialization or an equivalent subject.

Good knowledge of the English language, both written and spoken, is required as 
well as a great interest within the field of biophysics and/or biochemistry. A 
suitable candidate must also be creative, have good collaboration skills, have 
a high degree of independence, and problem-solving analytical ability. 
Experience of protein production and characterization and/or Linux 
terminal/programming are considered as merits.

Terms of employment
The appointment aims at a PhD degree and the main task of the PhD student is to 
pursue their doctoral studies, which includes participation in research 
projects as well as postgraduate courses. In the assignments, teaching and 
other departmental work (up to a maximum of 20%) can be included. The 
employment is limited to four years full-time or up to five years when 
part-time teaching. The salary placement takes place according to the 
established salary level for doctoral employment.

Application
A complete application, written in English or Swedish, should contain a 
Curriculum Vitae, a cover letter including a description of your research 
interests and motivation for applying for this position, copies of degree 
certificates or equivalent, including documentation of completed academic 
courses and obtained grades, name and contact information of at least two 
reference persons.

Applications must be submitted via our e-recruitment system (link at 
https://www.umu.se/en/work-with-us/open-positions/phd-student-position-in-chemistry-with-focus-on-biophysical-chemistry_267035/).
 The last day to apply is 2019-06-03.

For more information about the research, position, or other details, please 
contact Docent Magnus Andersson
email: magnus.p.anders...@umu.se
webpage: https://www.biostruct.umu.se/principal-investigators/magnus-andersson/

About us
The 

Re: [ccp4bb] Where is M.Harding's website for metal coordination geometry

[Elspeth Garman]

Hi
Eddie Snell and I were recently in contact with Marjorie Harding to track down 
her metal database website, and she told us that it is sadly no longer 
available since she retired from Edinburgh.
She thought an archived copy might be available if it could be dug out though.
Best wishes
Elspeth


From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Robbie 
Joosten
Sent: 07 May 2019 05:43
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] Where is M.Harding's website for metal coordination 
geometry

Hi Xiaoshan,

MetalPDB is not quite the same, but I like it a lot
http://metalweb.cerm.unifi.it

Cheers,
Robbie

n 7 May 2019 01:27, "Min, Xiaoshan" mailto:x...@amgen.com>> 
wrote:

Hi



I am trying to find out if the website  metal coordination groups in 
proteins is still accessible.   After some google 
search, I still can’t find it except this ccp4 newsletter  
http://www.ccp4.ac.uk/newsletters/newsletter40/15_metal_coord.html .   I trust 
that someone in this list might help me  find an alternative.



Thanks,



Xiaoshan





To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1