Hello, can you use the pisa server or similar to compare the extent of
domain-domain and domain-DNA contacts versus crystal contacts in your
structures? It might help to show which is the dominant factor affecting domain
orientation.
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On Tue, 28 May 2019 at
It is very difficult to demonstrate rigorously that crystal packing does not
favor a particular conformation. If you can show that the same conformation
occurs in solution (SAXS, NMR), or that the same conformation is found in a
different space group with different packing, then you have a
Hi All,
I has recently solved my X-ray structures of the ZnF domains of protein and its
complex with dsDNA. A structural comparison of holo-protein and the protein-DNA
binary complex reveals that the relative orientation of domains ZnF3 undergoes
a rotation of 50.5 degrees Does anyone know how
Hi All,
I has recently solved my X-ray structures of the ZnF domains of Bo and its
complex with dsDNA. A structural comparison of holo-Bo and the Bo-DNA binary
complex reveals that the relative orientation of domains ZnF3 undergoes a
rotation of 50.5 degrees Does anyone know how to show there
