Re: [Extropolis] Experimental drug​ cuts off pain at the source not the brain avoiding addiction

[John Clark]

On Tue, Jan 30, 2024 at 12:08 PM Henrik Ohrstrom 
wrote:

*> Everything that works causes some form of addiction.  I myself for
> example are quite addicted to my glasses and also oxygen.*
>

OK, but most people don't mind that they are addicted to those things but
most junkies wish they weren't addicted to heroin.

 > Of interest is side effects

I already mentioned those


>   >* does the drug take all sorts of pain? Just inflammation pain?
> Neurogenic pain? Phantom pain?*
>

I don't know, all I know is it operates on the peripheral nervous system
not the brain and it significantly helped about 2000 people who were in
pain because it was immediately after surgery.  Incidentally the Pakistani
family that had that rare mutation that blocked the operation of the gene
the drug is based on made money by staging exhibitions where they walked on
hot coals and cut themselves with knives.
 John K ClarkSee what's on my new list at  Extropolis

oim

ctn



>
>
> By studying a Pakistani family that has a rare mutation that renders them 
> unable
>> to feel pain, a small company called Vertex Pharmaceuticals has
>> developed a drug, that can be taken orally, that has shown significant
>> reduction in pain in two different drug studies with no clear adverse side
>> effects. The drug company found that 2 genes, called Nav1.7 and Nav1.8, are
>> needed for the peripheral nervous system to transmit pain messages to the
>> brain, their drug works by temporarily blocking the operation of Nav1.8
>> making it unable to manufacture the protein needed to transmit such pain
>> messages. In two different clinical trials, one with  1073 people who were
>> in pain and one with 1118, the patients reported a significant reduction in
>> pain and they experienced less nausea and fewer headaches then with
>> opioids, surprisingly even less than the control patients who received
>> placebos.  Because the drug targets the peripheral nervous system and has
>> no obvious effect on the brain it is unlikely to cause addiction. Right now
>> the drug is just called "VX-548" but if it's as good as it sounds and is
>> approved by the FDA it will be a huge blockbuster and I'm sure they'll
>> think of a catchier name.
>>
>>
>>
>> pnm
>>
>
>

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Re: [Extropolis] Experimental drug​ cuts off pain at the source not the brain avoiding addiction

[Henrik Ohrstrom]

Everything that works causes some form of addiction.  I myself for example
are quite addicted to my glasses and also oxygen.  I get severe withdrawal
symptoms if I go cold turkey on those things.
So talk about addiction or not is pointless.  Of interest is side effects
and effects,  does the drug take all sorts of pain? Just inflammation pain?
Neurogenic pain? Phantom pain?

/Henrik

Den tis 30 jan. 2024 15:18John Clark  skrev:

> By studying a Pakistani family that has a rare mutation that renders them 
> unable
> to feel pain, a small company called Vertex Pharmaceuticals has developed
> a drug, that can be taken orally, that has shown significant reduction in
> pain in two different drug studies with no clear adverse side effects. The
> drug company found that 2 genes, called Nav1.7 and Nav1.8, are needed for
> the peripheral nervous system to transmit pain messages to the brain, their
> drug works by temporarily blocking the operation of Nav1.8 making it unable
> to manufacture the protein needed to transmit such pain messages. In two
> different clinical trials, one with  1073 people who were in pain and one
> with 1118, the patients reported a significant reduction in pain and they
> experienced less nausea and fewer headaches then with opioids, surprisingly
> even less than the control patients who received placebos.  Because the
> drug targets the peripheral nervous system and has no obvious effect on the
> brain it is unlikely to cause addiction. Right now the drug is just called
> "VX-548" but if it's as good as it sounds and is approved by the FDA it
> will be a huge blockbuster and I'm sure they'll think of a catchier name.
>
>
>   John K ClarkSee what's on my new list at  Extropolis
> 
> pnm
>
> --
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> 
> .
>

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