RE: [NMusers] XPOSE4 cur.db error

Hi Paul, Thanks for the comments. I was wondering if, when you ask Xpose to read the files, you ask it to read run number '3' or '003'. I think the later should work if your files are named 'sdtab003' for example. -Andy Andrew Hooker, Ph.D. Assistant Professor of Pharmacometrics

RE: [NMusers] Xpose31 fails to be redirected to the working directory

. The other possible problem is the capital letters in your table file names...I don't work much with Xpose 3.1, but I always used to use lowercase letters when I did use it. Let me know if this helps! -Andy Andrew Hooker, Ph.D. Assistant Professor of Pharmacometrics Div. of Pharmacokinetics

[NMusers] NONMEM Intermediate Workshop - 2nd announcement

on methodological aspects of non-linear mixed effects model building and applied PKPD modeling. He has published over one hundred original research articles in the area of PK and PKPD. Dr. Andrew Hooker Andrew Hooker is an assistant professor of pharmacometrics at Uppsala University, Sweden

RE: [NMusers] Too many PRED-generated items in $TABLE

section and can then contain the other table values you need. Cheers, Andy Andrew Hooker, Ph.D. Assistant Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Tel: +46 18 471 4355

[NMusers] NONMEM Workshops for intermediate and advanced users

Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Div. of Pharmacokinetics and Drug Therapy Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 Mobile: +46 701 679 048 http://www.farmbio.uu.se/research.php?avd=5

RE: [NMusers] 20 variable limit in $INPUT

Hi All, PsN does this automatically when using the '-wrap_data' option of the 'execute' command. See http://psn.sourceforge.net/PDF_docs/common_options_defaults_versions_psn.pdf for more details. Best regards, Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Div

[NMusers] Uppsala pharmacometrics workshop before PAGE in June

for a wide range of PKPD models applied in different disease areas. The course will be given by Prof. Mats Karlsson, Dr Lena Friberg, Dr Andrew Hooker and Dr Ulrika Simonsson. A prerequisite for the course is experience with performing NONMEM analyses and basic knowledge of PK/PD models

RE: [NMusers] Calculating shrinkage when some etas are zero

Removing the ETA=0 before computation of the sd(ETA). Best regards Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 www.farmbio.uu.se/research.php?avd=5

RE: [NMusers] Time-to-event analysis with $DES

that the relative standard errors were significantly lower with this second parameterization. Best regards Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 http

Re: [NMusers] Epsilon shrinkage and IWRES

Hi rik If you have multiple eps() in your model then the default nonmem calculation will be wrong (understandably). In those instances I define iwres myself and calculate using the psn option -shrinkage. Best regards Andy On 22 sep 2011, at 17:14, Rik Schoemaker rik.schoema...@exprimo.com

RE: [NMusers] Memory problems with Xpose

change.xvardef(xpdb,var=covariates) - c(SEX,AGE,WT) # then run the plot again: parm.vs.cov(xpdb) The scope can also be changed in the classic menu system. Best regards Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University

RE: [NMusers] Error files when using multicore runs and psn == Fatal Error: Record SIZES is not valid

option but keep the xmloff option. You can find this information in the following documentation: http://psn.sourceforge.net/pdfdocs/common_options_defaults_versions_psn.pdf http://psn.sourceforge.net/pdfdocs/psn_configuration.pdf Best regards Andy Andrew Hooker, Ph.D. Associate

Re: PopDesign: [NMusers] PopED and SSE comparison

, fixing a parameter in an optimal design calculation can also be used to force a design to focus on other parameters in your model, but for predictions of RSE values one should always match how the estimation model will do things. Best regards Andy Andrew Hooker, Ph.D. Associate Professor

Re: [NMusers] XPOSE for R-3.1.1?

Hi Masaki, I find Xpose using both windows and mac versions of R-3.1.1. Perhaps you need to change the mirror that your R installation is pointing to? Best regards Andrew Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591

Re: [NMusers] Adding a greek letter in Y-axis label using xpose.VPC

created using the xpose.VPC command # Here I update the label for the first plot vpc_plots@plotList[[1]] - update(vpc_plots@plotList[[1]],ylab=expression(hat(beta))) Hope this helps. Best regards, Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences

[NMusers] PopED 0.1.2 available from CRAN

for a complete list of changes. More information about PopED can be found at http://poped.sourceforge.net. Best regards Andrew Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 Mobile

[NMusers] Xpose 4.5.3 available from CRAN

list of changes. More information about xpose can be found at http://xpose.sourceforge.net. Best regards Andrew Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 Mobile: +46

[NMusers] Workshop on PKPD-modeling in NONMEM

applied in different disease areas. A prerequisite for the course is basic experience with performing NONMEM analyses. For more information and registration, see www.uppsala-pharmacometrics.comhttp://www.uppsala-pharmacometrics.com. Best regards, Andrew Andrew Hooker, Ph.D. Associate

[NMusers] PODE 2016

any questions please do not hesitate to ask me. Best wishes, Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden www.farmbio.uu.se/research/researchgroups/pharmacometrics/<http://www.farmbio.uu

[NMusers] PODE 2016 and 3 day course on "Optimal Design for Pharmacometrics"

esign-for-pharmacometrics-registration-24567591327 If you have any questions please do not hesitate to ask me. Best wishes, Andy Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 Mobile

[NMusers] Course: Advanced methods for population model building and evaluation

iques and implementations in population models and will consist of both lectures and hands-on computer exercises using NONMEM 7, PsN and Xpose. For more information and registration, see: http://www.uppsala-pharmacometrics.com/build_diagnose_NJ_2017.html. Best regards, Andrew Andrew Hooker,

[NMusers] Course in model building and evaluation, Boston, MA, USA

s.com/build_diagnose_boston_2018.html Best regards, Andrew Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 Mobile: +46 768 000 725 www.farmbio.uu.se/research/researchgroups/pharmacometrics/

[NMusers] Last chance: Course in model building and evaluation, Boston, MA, USA

Dear all, Mats Karlsson and I (Andrew Hooker) will give a 2.5-day course on “Advanced methods for population model building and evaluation in NONMEM", 28-30 November, 2018 in Boston, MA, USA. The course presents the latest methods for model evaluation, strategies for model improvement as

[NMusers] 2 courses in NJ, March 9-13, 2020

2020.html Best regards, Andrew Andrew Hooker, Ph.D. Associate Professor of Pharmacometrics Dept. of Pharmaceutical Biosciences Uppsala University Box 591, 751 24, Uppsala, Sweden Phone: +46 18 471 4355 Mobile: +46 768 000 725 www.farmbio.uu.se/research/researchgroups/pharmacometrics/ När du

[NMusers] Two online NONMEM courses May 11-13 and 14-15

ww.uppsala-pharmacometrics.com. Course 1: Advanced methods for population model building, evaluation, and usage in NONMEM ===== May 11-13, 2020 Andrew Hooker & Mats Karlsson Pharmacometric modeling has become a pillar

[NMusers] Open positions in methodological research at the Pharmacometrics Group, Uppsala University.

have questions. Andrew Hooker andrew.hoo...@farmaci.uu.se<mailto:andrew.hoo...@farmaci.uu.se> Mats Karlsson mats.karls...@farmaci.uu.se<mailto:mats.karls...@farmaci.uu.se> Best regards, Andy Andrew Hooker, Ph.D. Professor of Pharmacometrics Dept. of Pharmacy Uppsala University Box

[NMusers] PhD position in pharmacometrics at Uppsala University, Sweden

trials (N-of-1 and N-of-few). The doctoral position is part of an EU funded Marie Sklodowska-Curie Action (MSCA) "doctoral network" called Medicines Made to Measure. Deadline for applying is November 27th, 2023. For more information visit https://lnkd.in/dvqKRyVu. Best regards, Andy And

Re: [NMusers] Distribution of CWRESI as a diagnostic

that the CWRESI are actually the CWRES by setting (CWRES=CWRESI) in the table file (not tested, but I suspect this will work). On a side note, I think my NMUSERS account is associated with my old “farmbio” email address, so maybe you could forward this to note to NMUSERS? Best regards, Andy Andrew