Hi Greg,
Thanks for your response.
Peter is exactly right. There is wide spread agreement that the pi electrons
of aromatic nitrogen atoms are not hydrogen bond acceptors. I do not have any
experimental data off the top of my head to prove this. However from first
principles, it is clear th
Hi Konrad,
You (and Peter later in the thread) make valid points about whether or not
particular functional groups are donors or acceptors. There are certainly
interesting discussions to be had about that - particularly when those
discussions are backed up by an analysis of experimental data - but
Speaking from the peanut gallery, that seems to me to be a rather important
point, at least as far as pyrrole NH is concerned. I assume there is
widespread agreement that these are not acceptors.
I think thiophene S is usually regarded as a receptor, albeit a weak one,
but F is highly debatable. S
Hi All,
The following is a relatively minor point, but IMHO, the Gobbi hydrogen bond
acceptor definition probably should be modified so that only aromatic nitrogen
atoms with two and not three non-hydrogen attachments are considered as
acceptors. For example, the aromatic nitrogen atom pyridin
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