Sorry I can't post a benchmark here, because I'm not in the office. Maybe I 
will do that tomorrow. I use vmprof and can just share a link to the 
uploaded profile. Will that suite you?

But I can say right now that I've passed only integers, not strings. Also 
mysqlclient encoding values if needed as far as I can see.

https://github.com/PyMySQL/mysqlclient-python/blob/master/MySQLdb/cursors.py 
see _do_execute_many at line 286.

And the fact that sqlalchemy doesn't make batches automatically is much 
worse than performance problems. Heuristics will not work one day, which 
means any inserts to the database should be surrounded with try catch etc.
sqlalchemy makes sql by ', '.join on values, which makes it impossible for 
it to see that the string size is to big until it's too late. I think it's 
better to use approach that mysqlclient is using, where they encode prefix 
and postfix query part into bytearray (which is mutable) and append 
arguments to it checking that the bytearray size is less then the limit.

-- 
SQLAlchemy - 
The Python SQL Toolkit and Object Relational Mapper

http://www.sqlalchemy.org/

To post example code, please provide an MCVE: Minimal, Complete, and Verifiable 
Example.  See  http://stackoverflow.com/help/mcve for a full description.
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