>Date: 20 May 2001 23:15:03 -0000
>To: List Member <[EMAIL PROTECTED]>
>Reply-To: [EMAIL PROTECTED]
>From: "Fuel and Fiber Company" <[EMAIL PROTECTED]>
>Subject: Genencor Identifies Structure of a Novel Fungal Cellulose: 
>Findings to Lead to the Development of Enzymes for More Efficient I
>
>Genencor Identifies Structure of a Novel Fungal Cellulose: Findings 
>to Lead to the Development of Enzymes for More Efficient Industrial 
>Processes
>Source: Source: Genencor International, Inc. / PRNewswire
>05/09
>
>
>Genencor International, Inc. (Nasdaq: GCOR) announced today (April 
>30, 2001) the publication, in a peer-reviewed journal, of results 
>describing the structure of a commercially important fungal 
>cellulase, Cel12A (EG3). This work will enable Genencor to develop 
>improved novel cellulase enzymes designed to enhance the efficiency 
>of industrial processes including the production of detergents, 
>textiles, food, paper and fuel alternatives such as ethanol.
>
>The paper, published in the Journal of Molecular Biology, entitled 
>"The X-ray crystal structure of the Trichoderma reesei family 12 
>endoglucanase 3 (Cel12A) at 1.9A," describes results from an 
>international collaboration between scientists at Genencor, and both 
>Uppsala University and the Swedish University of Agricultural 
>Sciences in Uppsala, Sweden. Using X-ray crystallography, the 
>scientists determined the specific structural features of the Cel12A 
>protein that provide important insight into the mechanism of action 
>of the protein.
>"This publication further validates Genencor's in-depth expertise in 
>fungal biology, protein chemistry, and crystallography," commented 
>Michael Arbige Ph.D., Senior Vice President of Research and 
>Development. "Such core competencies are an integral part of our 
>i-biotech(TM) solution, which integrates our full suite of 
>technologies, facilitating the rapid development of more effective 
>and safer biologically engineered materials for the consumer, 
>industrial and health care markets."
>
>Cellulases are a commercially important class of enzymes found in 
>fungal and bacterial microorganisms that utilize plant matter as one 
>of their primary carbon sources. They are responsible for the 
>degradation of plant cell walls and provide a fast and effective 
>means of releasing important fermentable sugars from plant matter. 
>By understanding the precise locations of amino acids within the 
>protein, Genencor can incorporate this information into its 
>molecular evolution and design platform to accelerate the natural 
>evolutionary process and genetically engineer, and optimize, 
>biomaterials in more advantageous ways. Furthermore, the integration 
>of these data into Genencor's immunology platform allows assessment 
>and elimination of potential allergenic risk from newly created 
>biomaterials. Novel enzymes derived from these processes will, for 
>example, be evaluated to enhance the technology for ethanol fuel 
>production from cellulose biomass.
>
>About Genencor
>Genencor International is a diversified biotechnology company that 
>develops and delivers innovative products into the health care, 
>agriculture, and industrial and consumer markets. Using an 
>integrated set of technology platforms, Genencor's products deliver 
>innovative and sustainable solutions to many of the problems of 
>everyday life.
>Genencor was established in 1982 as a joint venture between 
>Genentech Inc. and Corning Incorporated. Since its founding, 
>Genencor has grown to become a leading biotechnology company, with 
>over $315 million in annual revenues, more than 250 biotechnology 
>products in commerce, and over 3,400 owned and licensed patents and 
>applications. Genencor, with more than 1,500 employees worldwide, 
>has principal offices in Palo Alto, California; Rochester, New York; 
>and Leiden, the Netherlands.
>
>Except for the historical information contained herein, the matters 
>discussed in this press release may contain forward-looking 
>statements which involve risks and uncertainties, including 
>significant fluctuations in product performance depending on factors 
>such as a dependence on the efforts of third parties, a new and 
>uncertain technology employed by Genencor and its uncertain 
>application to new business ventures, dependence on intellectual 
>property rights, the competitive nature of Genencor's industry and 
>risks of obsolescence of certain technology. Actual results may 
>differ materially from those projected. Forward-looking statements 
>represent the judgment of Genencor as of the date of this release. 
>Genencor disclaims, however, any intent or obligation to update any 
>forward-looking statements.
>(C) 2001 PR Newswire. All rights reserved.
>
>_______________________________________________________________________
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