we have two of these devices here in the office and my coworker loves to use it for making notes and sketches.
i like the device's size for reading pdfs with annoying layouts, and i prefer this screen technology to the glaring normal displays i get to use otherwise. replace my main monitor with one of these and i might even run acme for a day for you. but with mouse and keyboard, i would never replace them with touch input. for sketches i'll keep on using paper and pen :)