Re: Pfizer or Oxford?
Vaccines have always been about risk management. Rare side effects/circumstances vs effectiveness of vaccine and severity of risk due to infection. If there was a risk of polio or small pox, the threat a vaccine may pose pales in comparison, for example.
As for vaccine types, the [AstraZeneca] vaccine essentially does the same thing the Pfizer vaccine does. It encodes the COVID spike protein that it uses to infect cells as DNA, and loads the payload into a chimpanzee adenovirus. That virus then enters your cells to instruct your cells to build the Spike protein to build antibodies.
The [Pfizer] vaccine actually slips in an mRNA data packet into your cells, like the [virus itself], but only for instructions for the virus's spike protein it uses to attack. The cells then manufacture the spike protein, sans viral payload to get a heads up on the attack vector it uses and builds an antibody defense. To understand that process a little better you can read [this], or [this].
The huge advantage with mRNA is that they seem to be more effective at being taken up and building antibodies, and are easier to manufacture, so you can make vaccines and booster shots and such very quickly that are very effective.
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