Title: [ccp4bb]: "negative" sequence numbers...
We’ve used negative residue numbers in refmac.  Works fine.

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REMARK   3   PROGRAM     : REFMAC 5.2.0005
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ATOM   2530  N   GLY B  -1      -5.374  41.007   6.196  1.00 39.06           N
ATOM   2531  CA  GLY B  -1      -6.696  40.946   6.815  1.00 37.77           C
ATOM   2532  C   GLY B  -1      -6.725  41.571   8.193  1.00 36.90           C
ATOM   2533  O   GLY B  -1      -7.758  41.544   8.871  1.00 37.01           O
ATOM   2534  N   HIS B   0      -5.584  42.123   8.607  1.00 35.59           N
ATOM   2535  CA  HIS B   0      -5.479  42.910   9.843  1.00 34.26           C
ATOM   2536  CB  HIS B   0      -4.758  42.131  10.944  1.00 34.28           C
ATOM   2537  CG  HIS B   0      -5.303  40.757  11.189  1.00 35.56           C
ATOM   2538  ND1 HIS B   0      -4.546  39.615  11.012  1.00 36.77           N
ATOM   2539  CE1 HIS B   0      -5.279  38.555  11.303  1.00 36.68           C
ATOM   2540  NE2 HIS B   0      -6.483  38.969  11.664  1.00 37.26           N
ATOM   2541  CD2 HIS B   0      -6.527  40.341  11.598  1.00 35.48           C
ATOM   2542  C   HIS B   0      -4.687  44.181   9.538  1.00 33.12           C
ATOM   2543  O   HIS B   0      -3.940  44.226   8.558  1.00 32.58           O
ATOM   2544  N   MET B   1      -4.846  45.209  10.367  1.00 31.04           N
ATOM   2545  CA  MET B   1      -4.087  46.445  10.203  1.00 29.04           C
ATOM   2546  CB  MET B   1      -4.409  47.394  11.355  1.00 29.22           C
ATOM   2547  CG  MET B   1      -3.455  48.562  11.497  1.00 28.45           C
ATOM   2548  SD  MET B   1      -4.346  50.080  11.789  1.00 28.70           S
ATOM   2549  CE  MET B   1      -5.334  50.213  10.305  1.00 27.54           C
ATOM   2550  C   MET B   1      -2.569  46.186  10.098  1.00 27.76           C
ATOM   2551  O   MET B   1      -2.029  45.331  10.806  1.00 27.56           O
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From: Garib Murshudov <[EMAIL PROTECTED]>
Date: Mon, 31 Jul 2006 13:49:00 +0100
To: Andrew Gulick <[EMAIL PROTECTED]>
Cc: <[email protected]>
Subject: Re: [ccp4bb]: "negative" sequence numbers...

refmac should be able to handle negative residue numbers. If not then we have introduced a bug and needs to be fixed.

Garib

On 31 Jul 2006, at 13:20, Andrew Gulick wrote:

I have a new structure in which I can see a residue N-terminal to the first methionine that is derived from the "left-over" gly-his that results after His-tag cleavage.  What is the proper way to label this residue (as far as sequence number) in order to have COOT and REFMAC properly handle the bond between the histidine and the "n-terminal" met?  (Should the residue number be 0?  -1?)

I've tried a negative sequence label.  I've also tried to insert a residue with COOT (figuring it will build and label it correctly) and it "fails to find any acceptable configuration." making me wonder if it won't look residue N-terminal to residue #1.

Thanks,
Andy


 
Andrew M. Gulick, Ph.D.
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