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> redundancy and signal-to-noise or increase exposure time but have a less
> redundant dataset.  So I guess the question comes down to whether multiple
> weak reflections is better than one strong reflections for SAD?  Does

Probably depends on your crystals...but increased redundancy/multiplicity
seems to correlate more with experimental map quality than other scaling
statistics, at least in my experience.

> anyone
> have any nice strategies for estimating/optimizing the exposure time for
> SAD/MAD datasets?  Also do people still like to collect inverse beam for
> C2
> spacegroups?  Any comments would be greatly appreciated.  Thank you very
> much.

Not sure about C2, but for C2221 at low resolution inverse beam/wedge
collection makes a surprisingly big difference, especially when the
anomalous signal is weak, or the crystals are otherwise not great.

Good luck,

Pete

Pete Meyer
Fu Lab
BMCB grad student
Cornell University

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