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Hi,
The program "Modeller" by Andrej Sali does exactly what you are looking
for. You can download the latest version at:
http://salilab.org/modeller/modeller.html
You need to register the software, but this is free of charge to
academic non-profit institutions.
Alexander Johs
Yong Tang wrote:
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>
>
> Dear all,
>
> I have a protein that has a homolog with known crystal structure. I
> aligned them manually and very carefully to make sure that we get what
> we have known right. I want to now replace the conserved residues in
> the model into those of my protein of interest and hopefully also do
> some sort of positional minimization so that I could have a rough idea
> about the surface of my protein of interest. Would there be any
> program doing this for me - that is, take the model pdb and my
> alignment file and generate a model for my protein of interest? If
> not, would you be kind enough to share your protocol with me if you
> have done this by hand. Happy Holidays!
>
> Thanks! -yong
>
