Dear All, does anyone have any clever suggestion/s for handling the solubility problem of highly hydrophobic compound, during co-crystallization or inhibition assays? The ligands I am using are almost insoluble in aquous medium (precipitates out or becomes turbid at ~1 micro molar conc.). In DMSO, the solubility is upto 50mM. Ligands are not soluble in MeOH or EtOH. Besides crystallization, this solubility is also a hindrance for in-vitro or in-vivo assays requiring higher conc. of ligand (keeping in mind, the final DMSO conc. <5%)! Some of the ligands have benzoic acid groups. Does it help to convert them to Na benzoate form? Thanks for your time, Tuhin.
Dept. of Physics Indian Institute of Science. -- This message has been scanned for viruses and dangerous content by MailScanner, and is believed to be clean.
