SUMMARY DESCRIPTION: Structural biology of virus-host interactions The Kvansakul Laboratory is seeking a postdoctoral fellow to investigate the structural basis of inhibition of programmed cell death during viral infection (e.g. Kvansakul et al 2007 Mol. Cell 25: 933 942, Kvansakul et al Cell Death Differ 2008 15: 1564 1571, Kvansakul et al 2010 PLoS Pathogens Dec 23;6(12):e1001236). This position offers the opportunity to work in a highly collaborative and stimulating environment. The Kvansakul Lab is part of the recently established La Trobe Institute for Molecular Sciences (LIMS) at La Trobe University, Melbourne, Australia. LIMS is a multidisciplinary institute that brings together the Departments of Biochemistry, Chemistry, Genetics and Pharmacy.
The successful candidate will have the opportunity to: 1. Express and purify viral and host proteins and their complexes 2. Investigate different host binding partners for viral effector proteins and their affinities 3. Crystallize and determine the macromolecular structure of these proteins and their complexes with ligands START DATE: The position is available immediately for 2 years in the first instance. REQUIREMENTS: Ph.D. in biochemistry, biophysics or structural biology. Experience with expression of recombinant proteins in a variety of hosts (bacteria, yeast, insects) and purification of proteins to a high degree of homogeneity are required. Prior experience with protein crystallization and structure determination is strongly desirable. Experience with biochemical assays and analyzing protein-protein interactions is also highly desirable. For more details see http://jobs.latrobe.edu.au/jobDetails.asp?sJobIDs=545338&lWorkTypeID=&lLoca tionID=&lCategoryID=&stp=AW&sLanguage=en For informal enquiries please email m.kvansa...@latrobe.edu.au or come to the IUCr 2011 in Madrid. APPLICATION: Closing date is September 11th. Please apply online at http://jobs.latrobe.edu.au/jobDetails.asp?sJobIDs=545338&lWorkTypeID=&lLoca tionID=&lCategoryID=&stp=AW&sLanguage=en
