Yes, this is a key paper demonstrating the possibilities. The answer to the question of first structure solved is a bit more difficult. Much of the early use of synchrotrons was for collecting high resolution data for refinement to supplement data collected on lab sources. This included data from similar structures with more or less sequence identity as well as data from heavy atom derivatives. MAD structures appeared somewhat later (see the references in Proc. Nati. Acad. Sci. USA Vol. 86, pp. 2190-2194, April 1989 for some early examples).
Of course John Helliwell's book (Macromolecular Crystallography with Synchrotron Radiation, chapter 10) gives a useful historical introduction. Other than the above, if anyone has a claim to first structure solved just with synchrotron radiation then they should speak up! Colin -----Original Message----- From: CCP4 bulletin board [mailto:[email protected]] On Behalf Of Harry Powell Sent: 13 March 2013 15:04 To: ccp4bb Subject: Re: [ccp4bb] first use of synchrotron radiation in PX Hi Not sure if this is strictly speaking the first protein *solved* on a synchrotron, but I think this is the first report of shooting protein crystals at a synchrotron in the widely available literature - http://www.pnas.org/content/73/1/128.full.pdf+html Phillips J C, Wlodawer A, Yevitz M M and Hodgson K 0 1976 Proc. Nat. Acad. Sci. USA 73 128-32 Applications of synchrotron radiation to protein crystallography: Preliminary results On 13 Mar 2013, at 14:38, Alan Cheung wrote: > Hi all - i'm sure this many will know this : when and what was the first > protein structure solved on a synchrotron? > > Thanks in advance > Alan > > > -- > Alan Cheung > Gene Center > Ludwig-Maximilians-University > Feodor-Lynen-Str. 25 > 81377 Munich > Germany > Phone: +49-89-2180-76845 > Fax: +49-89-2180-76999 > E-mail: [email protected] Harry -- Dr Harry Powell, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH Chairman of European Crystallographic Association SIG9 (Crystallographic Computing) -- This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail. Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments are free from viruses and we cannot accept liability for any damage which you may sustain as a result of software viruses which may be transmitted in or with the message. Diamond Light Source Limited (company no. 4375679). Registered in England and Wales with its registered office at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom
