Sivaraj Ramesechan was outlining the physics of multiple wavelength anom scattering in the 1960s as a method for solving insulin. It was purely theoretical then; no instruments to make the measurements.. Eleanor
On 13 Mar 2013, at 17:19, Peter Moody wrote: > When I started my PhD (in 1980!) at Imperial, David Blow already had a PhD > student who's project was to use the new Daresbury synchrotron to exploit > anomalous differences. Unfortunately it didn't come on line in time for him > to actually get the data he needed. > I'd be intrigued to know who got the first structure from Daresbury. I don't > remember feeling there was a race at the time, but then we were a lot less > competitive in those days! > Peter > > On 13 March 2013 16:21, Colin Nave <[email protected]> wrote: > Yes, this is a key paper demonstrating the possibilities. > > The answer to the question of first structure solved is a bit more difficult. > Much of the early use of synchrotrons was for collecting high resolution data > for refinement to supplement data collected on lab sources. This included > data from similar structures with more or less sequence identity as well as > data from heavy atom derivatives. MAD structures appeared somewhat later (see > the references in Proc. Nati. Acad. Sci. USA Vol. 86, pp. 2190-2194, April > 1989 for some early examples). > > Of course John Helliwell's book (Macromolecular Crystallography with > Synchrotron Radiation, chapter 10) gives a useful historical introduction. > > Other than the above, if anyone has a claim to first structure solved just > with synchrotron radiation then they should speak up! > > Colin > > -----Original Message----- > From: CCP4 bulletin board [mailto:[email protected]] On Behalf Of Harry > Powell > Sent: 13 March 2013 15:04 > To: ccp4bb > Subject: Re: [ccp4bb] first use of synchrotron radiation in PX > > Hi > > Not sure if this is strictly speaking the first protein *solved* on a > synchrotron, but I think this is the first report of shooting protein > crystals at a synchrotron in the widely available literature - > > http://www.pnas.org/content/73/1/128.full.pdf+html > > Phillips J C, Wlodawer A, Yevitz M M and Hodgson K 0 1976 Proc. Nat. > Acad. Sci. USA 73 128-32 > > Applications of synchrotron radiation to protein crystallography: > Preliminary results > > > On 13 Mar 2013, at 14:38, Alan Cheung wrote: > > > Hi all - i'm sure this many will know this : when and what was the first > > protein structure solved on a synchrotron? > > > > Thanks in advance > > Alan > > > > > > -- > > Alan Cheung > > Gene Center > > Ludwig-Maximilians-University > > Feodor-Lynen-Str. 25 > > 81377 Munich > > Germany > > Phone: +49-89-2180-76845 > > Fax: +49-89-2180-76999 > > E-mail: [email protected] > > Harry > -- > Dr Harry Powell, MRC Laboratory of Molecular Biology, Francis Crick Avenue, > Cambridge Biomedical Campus, Cambridge CB2 0QH Chairman of European > Crystallographic Association SIG9 (Crystallographic Computing) > > > > -- > > This e-mail and any attachments may contain confidential, copyright and or > privileged material, and are for the use of the intended addressee only. If > you are not the intended addressee or an authorised recipient of the > addressee please notify us of receipt by returning the e-mail and do not use, > copy, retain, distribute or disclose the information in or attached to the > e-mail. > > Any opinions expressed within this e-mail are those of the individual and not > necessarily of Diamond Light Source Ltd. > > Diamond Light Source Ltd. cannot guarantee that this e-mail or any > attachments are free from viruses and we cannot accept liability for any > damage which you may sustain as a result of software viruses which may be > transmitted in or with the message. > > Diamond Light Source Limited (company no. 4375679). Registered in England and > Wales with its registered office at Diamond House, Harwell Science and > Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom > > > > > > > > > >
