Dear all

I have a somewhat philosophical question. Why do all protein sequences start 
with a methionine (not referring to mature/processed form)? What is so special 
about methionine and cannot be replaced by other amino acids?

Second, how does the ribosome know the first start codon is for methionine when 
the codon is not AUG? This is about the alternative start codons like GUG.

Thank you.

Theresa

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