> > >Happy Holidays. > > >Please review the position specifications and advise if someone in your >network may have an interest in finding about more about this exciting >Crystallography opportunity with DNS. > > >Opportunity: DNS offers competitive salaries and a great benefits package >including incentive bonuses, healthcare, vision, dental, long-term disability, >life insurance and a 401(k) retirement savings plan. > > > >Position: Scientist III-Iv/ Manager/ Group Leader – Structural Biology – >Crystallography > >Client: Dart NeuroScience LLC (DNS) is a privately held Delaware Limited >Liability Company with offices in San Diego, CA. DNS will discover new >technologies and develop new therapies to help maintain cognitive vitality >throughout life. > >DNS is seeking a group leader with a strong background in macromolecular >crystallography. >Reporting to the director of structural biology, the successful candidate will >be responsible to establish and manage the crystallography team within the >group. > >The candidate should have expert knowledge of the state-of-the-art >crystallization and structure determination equipment and processes necessary >to produce high-quality crystal structures and to support structure-guided >drug design. > >Major responsibilities will include independent hands-on experimental work and >leading a team of scientists and research associates to support >high-throughput crystallization, X-ray data collection, structure >determination and refinement of high-quality protein structures originating >from different protein families including membrane proteins. > >The candidate will be required to give scientific expert advice to group >members and have frequent interactions with the molecular biologists, protein >production team and protein chemists in the group to provide ideas on new >protein boundary designs, incorporation of mutations that alter protein >function and stability and on new ideas to improve protein expression and >purification yields, crystallizability and diffraction quality of protein >crystals. > >The candidate will also interact closely with computational and medicinal >chemists in the company to propose new ideas for structure-based combinatorial >libraries, inhibitor design, or variants of existing compounds that may be >useful in advancing project goals. > >Good communication skills, leadership skills, project and sample management >experience overseeing multiple projects in parallel as well as capacity for >strategic thinking are required. > >Requirements & Responsibilities: > >· Ph.D. in life science with thesis. > >· 8+ years of relevant experience in protein crystallography and >structure-guided drug design. Preferably 1+ year of industrial supervisory >experience of Ph.D. scientists and research associates. > > > >· Proven hands-on experience in high-throughput crystallization, >synchrotron data collection, structure determination, structure refinement, >structure-based drug design and fragment-based drug discovery. > >· Familiar with all major crystallography software packages (HKL, CCP4, >COOT, Pymol). > >· Expert knowledge in the scientific principles and concepts of protein >crystallography including state-of-the-art high-throughput crystallization, >phasing (MAD/SAD/MR), density modification, model building, refinement and >structure validation. > >· Knowledge in other areas of structural biology (protein chemistry and >crystallography) and membrane protein crystallography is desirable. > >· Inter-disciplinary knowledge of drug discovery (enzymology, cellular >pharmacology, DMPK) is a plus. > >· Demonstrated independent thought/creativity in science. > >· Excellent collaboration, communication (oral and written) and >multitasking skills and able to present work formally to Scientific Research >Committees. > > > >For Additional Information Please Contact Bill Domann - Founder/ CEO The >Domann Organization, Inc. @ Email: [email protected] >or Jovanna Bost @ [email protected] > > > > > > > > > > > > >
