Dear Shane, Human antithrombin III (code 1ath) is a dimer of an active and latent conformation.
Herman Von: CCP4 bulletin board [mailto:[email protected]] Im Auftrag von Shane Caldwell Gesendet: Montag, 27. Januar 2014 19:09 An: [email protected] Betreff: [ccp4bb] Examples of multiple ASU copies with different conformations Hi ccp4bb, I'm putting together a talk for some peers that highlights strengths and weaknesses of structural models for the outsider. For one point, I'd like to find some examples of proteins that show very different conformations between different copies in the ASU. One example I know of is c-Abl (1OPL), which crystallizes with both autoinhibited and active forms in the ASU, with dramatically different domain organization. I'd like to find some additional examples - can anyone suggest some other structures that have multiple copies with large structural variations? Thanks in advance! Shane Caldwell McGill University
