Dear Shane,
To add a bit of detail to Frank von Delft's suggestion,
perhaps the best example is the structure of the yeast F1-ATPase that has 3
copies in the asu, from David Mueller's lab in Chicago. Two of these are very
similar, but the third is rather different and shows a (physiologically
relevant) phosphate binding site that is not found in the other two copies. I
would not describe the differences as dramatic though.
The paper is: Kabaleeswaran et al., EMBO J 25, 5433 (2006)
PDB ID 2HLD
Best wishes,
Andrew Leslie
On 27 Jan 2014, at 18:08, Shane Caldwell <[email protected]> wrote:
> Hi ccp4bb,
>
> I'm putting together a talk for some peers that highlights strengths and
> weaknesses of structural models for the outsider. For one point, I'd like to
> find some examples of proteins that show very different conformations between
> different copies in the ASU. One example I know of is c-Abl (1OPL), which
> crystallizes with both autoinhibited and active forms in the ASU, with
> dramatically different domain organization. I'd like to find some additional
> examples - can anyone suggest some other structures that have multiple copies
> with large structural variations?
>
> Thanks in advance!
>
> Shane Caldwell
> McGill University
>
>
