Hi All,

along those lines, phenix.find_tls_groups (also in the GUI) available in
Phenix since 2010, the tool splits model into TLS groups fast (up to a
minute). Some notes on underlying method:

https://phenix-online.org/phenixwebsite_static/mainsite/files/presentations/latest/afonine_find_tls_groups.pdf

Pavel

On Fri, Jul 17, 2026 at 7:44 AM John Bacik <
[email protected]> wrote:

> Hi Carlos,
>
> If it’s helpful, I have developed a Python-based tool for TLS segment
> optimization based on the published TLSMD algorithm. I have been testing it
> myself and plan to make it available on GitHub once I’ve cleaned it up a
> bit, but I would be happy to share the current version if you would like to
> try it.
> All the best,
> John
>
>
>
> On Thursday, July 16, 2026 at 04:10:47 AM CDT, Carlos CONTRERAS MARTEL <
> [email protected]> wrote:
>
>
> Hi
>
> somebody knows if the Ethan Merrit TLS Motion Determination Home (TLSMD
> server) will be back to life on day?
>
> http://skuld.bmsc.washington.edu/~tlsmd/
>
>
> or if there is a mirror somewhere ?
>
> All the best
>
> Carlos
>
>
> --
>           Carlos CONTRERAS MARTEL, Ph.D.
>                   (CRHC CNRS)
>
>           [email protected]
>
>               "Pneumococcus Group"
>         Institut de Biologie Structurale
>               UMR5075 CEA-CNRS-UGA
>
>               IBS (PG)
>               Campus EPN
>               71, avenue des Martyrs
>               CS 10090
>               38044 Grenoble CEDEX 9
>               FRANCE
>
>
>   tel : (+33) (0)4 57 42 86 41
>
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