Thankyou Dorothy,
Your message was very helpful...I was wondering if I managed to have two seperate problems to deal with and was a bit worried. Its funny I took genetics 30 years ago...but so much has changed and I have forgotten what little I knew, ha. Better start brushing up. I do not know what my level was when I was diagnosed...they just did a karyotype to see if I had the Philadelphia Chromosome. So I am not sure what a pcr result of 0.131% for b2a2 and 0.324 % for b3a2 means in terms of level of response. I had been on 400mg and was moved up to 600mg after the test. After two days I do not see any different symptoms or side effects...hope it stays this way. Its too early to get excited...but at 400mg I had a sort of low grade headache nearly all the time...sort of a pain in the back of my neck...but it has actually gone away with the 600mgs...probably it is unrelated...but if this is the only change I am happy, ha. Thanks again for your post. I hope you continue to get better and better results. Dan --- In [EMAIL PROTECTED], Dorothy Emery <[EMAIL PROTECTED]> wrote: > Hi Dan > > I can add some information here as I've read up on this in the past as I > too have pcr tests showing both b3a2 and b2a2. I read recently that > about 30% of cmler's show both so it's not that rare. It also has no > prognostic significance. I get my pcr test done at MDACC and they don't > show a separate % for the two breakpoints--I get only one pcr number. > I've been on Gleevec for over 4 years and have had a slowly lowering pcr > for almost the whole time. Early on my tests would always show both > breakpoints but as I got closer and closer to the limit of detection it > always just showed one or the other. When I saw this on my first pcr > test I wondered (and worried) why I would have both breakpoints-- did > this mean I had gotten leukemia twice?? I finally found the answer to > that and it is no. What happens is that sometimes the same dna > transcribes one way and sometimes another--both come from the same > original stem cell. If I get a chance I will look for the papers I've > read that referred to this and send them on to you if you are > interested. I'm just telling you what I remember right now without > actually looking up the original information--but I've got a pretty good > memory for this kind of stuff so I think the general idea is accurate. > > Best wishes, > Dorothy > > skink1100 wrote: > > > > > Tracy and Richard, thanks for the help in interpreting my pcr test. > > It is interesting why there would be multiple breaks. Is this > > common? Do most have multiple breaks or most have a single break. > > It seems that a multiple break requires multiple independent > > translocations...but perhaps I don't understand the mechanism well > > yet...that is certainly the case, ha. > > > > If anyone out there has info on this or something I could read...I > > would be interested. > > > > Dan > > > > > > > > > > > > > > > > New! Sign up for local CML support group meetings in your local > > community at http://cml.meetup.com > > > > Apply for Commercial Real Estate loans online and submit your deal to > > dozens of hungry lenders in just minutes. Loan programs for all types > > of business and commercial real estate. 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