Marcia,
Ouch, you've really had a time of it.  I have been on Gleevec for 
little over a year and have had no where near the level of cramps you 
have had.  Do you drink lots of water through the day?  It is suppose 
to reduce the toxicity of the medicine.  The cramping areas have 
stayed the same for me too.  I wonder if age has anything to do with 
the level of severity, it seems the 'more mature' folks experience 
more severe side effects, I'm 43.  What is everyone elses take on 
this?   




--- In [email protected], "Marcia Beaudry" <[EMAIL PROTECTED]> wrote:
>  
>  
> Hello Brenda,
> My name is Marcia, I am 51 years old and have been on 400mg. for 
2.5 years! I have the most debilitating cramps in both thighs that I 
am paralyzed in the dark, only help is to scream for my husband to 
bring ice bags that I have made up. There is no warning and my legs 
feel sore for the whole next day. I am not sure about you but I get 
them at the same time in the same spot of both legs. But the is does 
help. My biggest problem now is this horrible test in my mouth, I 
have no desire to eat because It's like poison or something, has 
anyone else experienced this? I have now lost 7lbs. in 3 months, and 
when I do eat it passes right thru! I am really weak at times so I am 
looking at some clinical trials, sine they are saying there are less 
side effects, but I haven't heard anything officially yet. But on the 
brighter side I am still here, and continue to  be POSITIVE, and the 
key word BRAVE.  Good luck to you........ Marcia
> --- On Mon 07/11, Brenda Morelli &lt; [EMAIL PROTECTED] &gt; 
wrote:From: Brenda Morelli [mailto: [EMAIL PROTECTED]: [EMAIL PROTECTED]: Mon, 
11 Jul 2005 19:38:08 -0000Subject: [CML] Re: Help (Nancy)Nancy,This 
is one of the most common side effects of Gleevec (cramping).  I had 
the same effects as you in the beginning, calves and feet/toes.  the 
only thing that would help was walking them off and it would 
sometimes be 15 or 20 minutes before they would stop.  After 6 months 
and as time has passed the cramping has lessened and are further and 
further a part in occurrences.  Potassium and calcium may help.  I 
just hope you don't get one of those big ones when your sleeping.  I 
had that happen to me several times and it was so annoying and 
disorienting.  Good luck and I hope the cramping improves soon.  Take 
care,Brenda--- In [email protected], nancy sprowl wrote:&gt; I just 
woke up with a terrible cramp in my left calf.I hang on the the wall  
and tried  to work this 
> cramp out,screaming in pain.It seemed like forever,but  in about 10 
minutes the pain started to stop.Then I got a foot cramp in my right 
foot .worse then the left leg.I cant sit, the pain is unbearable.I 
tried to move around applying pressure on the foot,screamin in 
pain,praying for the pain to go away.The pain was so bad I was 
crying.Finally it stopped ,but I am so exhausted from those 20 
minutes of torture.&gt; Does anyone  have any help for this? I never 
had cramps and pain like this before the "gleevec".&gt;        
Thanks.....Nancy&gt; &gt;             &gt; ---------------------------
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